Australasian Bioethics Information

Friday, 22 August 2003 · No. 89         ISSN 1446-2117
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BIOETHICS: Verfaillie scores again with adult stem cells

IN THIS WEEK'S NEWSLETTER

  • Verfaillie scores again with adult stem cells
  • Nitschke slams euthanasia conscience vote
  • Singapore births plummet
  • Prescribing drugs for kids can be risky
  • India to introduce death penalty for fake drugs
  • Nature may tighten disclosure rules
  • Egg donation: new career option for Indian women
  • IN BRIEF: thalidomide; Brazil; Vatican on cloning; lost dad
  • Feature: commercial realities of US IVF
  • ABI publications this week

    Verfaillie scores again with adult stem cells Catherine Verfaillie

    In another advance for adult stem cells, Catherine Verfaillie of the University of Minnesota has induced adult bone marrow stem cells to differentiate into cells of the mid-brain. This discovery suggests that these cells may some day be useful in treating Parkinson's disease and other disorders of the central nervous system. Her research has been reported in the current issue of the Proceedings of the National Academy of Sciences. The multipotent adult progenitor cells (MAPCs) described by Dr Verfaillie appear to have much the same versatility as embryonic stem cells (ESCs). They have been described as a way of bypassing the ethical problems raised by the use of ESCs. However she insists that both strands of research should continue "to determine which stem cells are most useful in treating a particular disease". ~ press release from Uni Minnesota, Aug 19

  • Geron, the Californian biotech firm which specialises in human ESCs, says that it has successfully transplanted human heart cells derived from ESCs into the hearts of healthy rats. The cells appear to be dividing and forming new heart tissue. Geron says that other studies will show whether transplanted human cells can help rats which have had heart attacks. ~ Reuters, Aug 20  

    Nitschke slams euthanasia conscience vote

    Dr Philip Nitschke Politicians should not be allowed a conscience vote on euthanasia, campaigner Dr Philip Nitschke said in a Sydney debate this month. "That has led us to where we are now," he said. "We are driven to more strategies and initiatives (such as plastic bags and carbon dioxide generators) that will ultimately let people go down this path whether politicians pass legislation or not."

    Dr Nitschke said that his group was no longer seeking to change the law. "We've effectively abandoned the legislative solution; we are pursuing a technical solution. And it's not difficult to do; this is not a cure for cancer we're looking for."

    In the course of his public debate with Catholic bioethicist and bishop- elect Professor Anthony Fisher at the University of Sydney, Dr Nitschke also advocated infanticide. "If a child is born and one can only see that that child will lead a life which is not worth living, as assessed by the person whose child it is, it (should be) sometimes appropriate for the child to have its life ended," he said. ~ Catholic Weekly (Sydney), Aug 24 

    Singapore births plummet

    Singaporeans are debating the reasons for their plummeting number of births. Recent figures show that it is on track to recording the lowest number of births in 26 years. Former Health Minister Lim Hng Kiang has been put in charge of a committee to boost marriages with children.

    Economic reasons are often cited. In financial downturns in 1986 and 1998, there were significant drops in the number of births. The medical director of the Thompson Fertility Centre, Dr Cheng Li Chang, says that "raising children is becoming more costly, especially since our education system is so competitive."

    But the chairman of Family Matters! Singapore, Chan Soo Sen, disagrees, saying "It's easy to blame the recession for the decline, but the main reason is that people don't view it as a priority." In fact, a generous 2001 baby bonus program which gives cash for six years to parents who have second and third children, appears to have failed -- perhaps, says sociologist Paulin Straughan, because the incentives are largely financial. People could not be blamed for putting their careers first after long, hard years in education. ~ Straits Times, Aug 20

  • The director of a psychiatric hospital in China's Guangdong province has been charged with selling patients as wives. Dr Wang Chaoying had sold more than 20 women for "thousands of yuan". drugging them first to conceal their illness. Some men later demanded refunds. As a result of its one-child policy, China's birth rate is skewed towards males, which has created a population of 70 million bachelors and a growing shortage of potential wives. ~ Guardian, Aug 20 

    Prescribing drugs for kids can be risky

    Most drugs are never tested for safety on children and paediatricians have to calibrate doses by guesswork and experience, say researchers from the US Food and Drug Administration in the latest issue of the Journal of the American Medical Association. Furthermore, some drugs developed for adults have been found to cause a higher incidence of death, seizures and suicidal thoughts in children.

    "Most of the tools we use as paediatricians are kind of hand-me- downs that have been tested and tried in adults," a specialist in neonatal intensive care told the Boston Globe. The problem is that children are not simply smaller adults, but have a different physiology. The US Congress is considering a bill which would require that drug companies test new drugs for safety, effectiveness and dosing information for children, but it faces stiff opposition. Its opponents say that requiring special trials for children would slow down approvals of new drugs and make it more difficult to bring drugs to market. ~ Boston Globe, Aug 20 

    India to introduce death penalty for fake drugs

    The magnitude of the counterfeit drug problem in India is so great that an expert committee has recommended that the maximum penalty for sale or manufacture should be death. "Profiting from spurious drugs that might harm or kill innocent people is equivalent to mass murder," said Health Minister Sushma Swaraj. A government survey found recently that 9% of drug samples were of poor quality and that fake medicines made up 0.3% of the samples.

    Amongst the counterfeited medicines are antibiotics, cough syrups (some with double the legal codeine level) and drugs for tuberculosis and malaria. Past investigations have uncovered drugs containing chalk powder. The committee says that India is plagued by inadequate drug testing, a shortage of drug inspectors and lack of enforcement. ~ bmj.com, Aug 23 

    Nature may tighten disclosure rules

    The editors of the Nature group of journals are considering broadening the scope of their requirements for disclosure of conflicts of interest after a complaint surfaced in the New York Times. After two US researchers were rebuffed by Nature Neuroscience, they complained in the mainstream press that the author of a review article had significant but undisclosed financial interests in three therapies which had received a favourable review.

    The executive editor of the Nature research journals, Charles Jennings, says that his group is studying whether the authors of reviews should also be asked to provide disclosure. Last year the New England Journal of Medicine was forced to relax its requirements to allow its authors to receive up to US$10,000 from interested companies because it was unable to find authors willing to contribute if the amounts were lower.

    Mr Jennings told The Scientist that good disclosure policies were needed to maintain public trust. "If the public comes to believe that basic science is systematically tainted by researchers' financial interests, that is not good for science, regardless of whether the public perception is accurate or not." ~ The Scientist, Aug 14 

    Egg donation: new career option for Indian women

    Egg donation is opening up as a "career option" for Indian women, like professional blood or kidney donors, says The Telegraph newspaper of Calcutta. The Indian Council of Medical Research has approved guidelines for doctors which allow them to buy eggs from women, usually for between 10,000 and 25,000 rupees.

    IVF specialists from Leelavati Hospital told The Telegraph that they prefer young married women, under 33, who have already proved their fertility by giving birth. Although the donors are mostly women from poor families, university students also offer to sell their eggs.

    Some Calcutta doctors are firmly opposed to paid egg donation. "Soon there could be a racket starting with some men having a group of women whose eggs they could sell," says Dr R. Soonavala. The IVF procedure is also risky for the donor because of the dangers posed by ovarian hyperstimulation, anaesthesia and egg extraction. ~ The Telegraph (Calcutta), Aug 17 

    IN BRIEF: thalidomide; Brazilian drugs; Vatican on cloning; lost dad thalidomide

  • Thalidomide, the drug which caused a world-wide epidemic of deformed babies in the 60s, is to be registered for use in Australia again. The Australian Drug Evaluation Committee has recommended that it be made available to treat multiple myeloma, a bone marrow cancer, and ENL, a complication of leprosy. ~ ABC on-line, Aug 20

  • Brazil's drug industry regulator has ordered three companies -- Eli Lilly, Bayer and Pfizer -- to suspend massive advertising campaigns for their anti-impotence drugs. The regulator argued that advertising for specific prescription drugs is illegal and that many people are using the drugs without medical guidance and as replacements for stimulants like crack and cocaine. ~ Pharma R&D Net, Jul 30

  • A Vatican official has explained that from a Catholic point of view, "therapeutic" cloning is even worse than reproductive cloning. Writing in L'Osservatore Romano, Cardinal Alfonso Lopez Trujillo contends that at least reproductive cloning is a form of artificial reproduction, while therapeutic cloning involves the creation and destruction of embryos, making it equivalent to murder in his eyes. ~ L'Osservatore Romano, Aug 9

  • A 13-year-old British boy has won a six-year legal battle to discover whether the man he called Dad was really his father. It turned out that there had been a mix-up in sperm donors for his mother's IVF treatment and that the man, whom he disliked, was not his father. The chair of the British Fertility Society said that she regretted the incident, but that "it was a long time ago and processes have improved greatly since then". ~ Sky News, Aug 22 
  • FEATURE: commercial realities of US IVF

  • Internet sperm marketing reaches lift-off
  • Sex selection goes mainstream
  • "A baby or your money back", say IVF clinics

    Internet sperm marketing reaches lift-off

    Although the legal development of IVF regulation in the UK receives more media coverage, more is actually happening in the US. In the UK the use of human embryos in medicine and research is regulated by a government watchdog. Controversial developments are scrutinised by the regulator or in the courts and often surface in the media. However, in the US, where there is almost no regulation, it is only infrequent special investigations by the media which bring new developments to light.

    As an example, the first British baby conceived with sperm bought on-line was born recently to an infertile couple in south-east England. The incident was treated as a novelty by the British press. However, on-line sperm banks have been operating in the US for some time. According to the Chicago Tribune, 40% of the clients of California Cryobank, one of the few 115 American sperm banks which meets industry standards for infectious disease and genetics testing, are single women and lesbians. The other 60% are married couples who are seeking a donor similar to the husband.

    This and other sperm banks provide on-line baby pictures and personality test results. "The trend is more and more corporate- marketing-oriented," says Terri Kapsalis, a health worker who is writing a book about sperm banks. "Reproductive medicine has become a cash cow for practitioners serving unmarried women who used to be denied services or made to undergo psychological testing before insemination."

    As an example of the sophistication of sperm marketing, Fairfax Cryobank, in Virginia, has created "Fairfax Doctorate", a special category of sperm from donors with PhDs. "People like to buy educated sperm," comments the director of Midwest Sperm Bank, which advertises only on the internet. ~ BBC, Aug 19; Chicago Tribune, Aug 20 

    Sex selection goes mainstream

    Sex selection advertisements for a Virginia fertility clinic are running in the New York Times, the first time that the procedure has been marketed in a mainstream American publication. The Genetics & IVF Institute (GIVF) offers an "exclusive scientifically-based sperm sorting gender selection procedure" called MicroSort which can be used to prevent sex-linked genetic diseases or for "family balancing". Although two years ago the Times exposed fertility clinics advertising sex selection aimed at Indian expatriates in the US, it has failed to report similar ads in its own pages -- and on the internet, where GIVF is quite prominent. Marcy Darnovsky, of the Center for Genetics and Society, observes that the GIVF marketing techniques use "a classic consumer come-on", by offering "FREE MicroSort" for customers who sign up for the invasive and potentially dangerous procedures of egg donation or preimplantation genetic diagnosis.

    Darnovsky comments that if sex selection become an established business in the US, "people and policy makers in other parts of the world will take note" -- including the UK, where the IVF regulatory body is studying the question of sex selection. Feminists also contend that acceptance in the US will worsen the lot of women in South Asia. "It is hard to overstate the outrage and indignation that MicroSort prompts in people who spend their lives trying to improve women's lot overseas," Fortune magazine has commented.

    Market research suggests that about a quarter of Americans would like to be able to select the sex of their child. Analysts say that the market for sperm sorting in the US alone amounts to between US$200 and 400 million, if it is "aggressively marketed". ~ Genetic Crossroads newsletter, Aug 20 

    "A baby or your money back", say IVF clinics

    Intense competition amongst the nearly 400 IVF clinics in the US has led more than one third of them to offer money-back guarantees for their treatment. The typical package is three or four IVF cycles for a fixed price, with the clinic gambling that most of their customers will fall pregnant within three cycles. However, all of the refund programs have non-refundable charges for diagnostic screening tests so that the clinics can refuse high-risk cases.

    In the US, where health insurance covers IVF treatment in only 15 of the 50 states, three no-frills IVF cycles can easily cost US$35,000. As an example of a cut-rate deal, Shady Grove Fertility Clinic in Maryland offers four-cycles for $20,000.

    Critics of IVF refund programs accuse the clinics of misleading advertising. Dr Nanette Santoro, of Albert Einstein College of Medicine, wrote in Endocrine Society News that "in fact, a large clientele that subscribes to the money-back guarantees improves the cash flow for an IVF clinic, as these couples usually pre-pay for their three cycles in advance. The principle is similar to other forms of high-stakes gambling. The house always wins."

    The clinics' need to complete the IVF treatment within three or four cycles is an incentive for doctors to implant several embryos to ensure that at least one takes. "The situation creates potential for distortions of medical decision making that can indeed do harm to the couple. The treating physician has an inherent conflict of interest in the outcome of the cycle," says Dr Santoro. ~ Philadelphia Inquirer, Aug 17; Endocrine Society News, Dec 2002 

  • ABI publications this week

    Has experimenting on human life lost its power to disgust?
    by Michael Cook, The Age (Melbourne), Aug 19



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    Australasian Bioethics Information
    ISSN 1446-2117
    Website:www.australasianbioethics.org
    Director: Dr Amin Abboud
    Editor: Michael Cook
    New Zealand Associate: Carolyn Moynihan