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In BioEdge 110
Bush stacks bioethics council against therapeutic cloning: sacks two, adds three
New PR strategy for therapeutic cloning campaign: focus shifts from cures to research
Dolly's creator backs cloned babies: only in extreme circumstances
Nitschke cooking up a "peaceful biscuit": DIY recipe for suicide
Genetically modified athletes on the horizon: gene therapy gives animals greater strength
Costa Rican president wins prize for opposing cloning: says No to all forms
UK entrepreneur hawks human eggs on the internet: reliable international service promised
Embryo screening first for Melbourne: number of screenable diseases grows
UK bioethicist backs infanticide: if before birth, why not after?
Starting life in a Petri dish may harm embryos: mouse study points to human problems
IVF families in the news: unique combinations
The bioethicist as hero: courage needed, says Savulescu
Bush stacks bioethics council against therapeutic cloning
President George W. Bush has stunned American scientists by reshuffling his influential bioethics advisory council to create a majority which is opposed to therapeutic cloning. Until now the 17- member council has been paralysed by unbridgeable differences of opinion. Its recent report on the most contentious issue in contemporary bioethics, stem cell research, spanned 400 pages and failed to express an opinion.
However, with the ejection of Australian Elizabeth Blackburn, from the University of California at San Francisco, and theologian William May, of the University of Virginia, the council's director, Dr Leon Kass, will be able to take a firm stand against all forms of cloning and and be more critical of other forms of reproductive technology.
Three new members have been appointed to the council. Dr Benjamin Carsons, of Johns Hopkins University, is best known for trying to separate adult conjoined twins from Iran last years. An Afro-American, he often invokes the Bible and has lamented that "we live in a nation where we can't talk about God in public". Diana Schaub, of Loyola College in Maryland, is a strong supporter of Dr Kass's conservative views on bioethics. Peter Augustine Lawler is a respected political science academic who opposes abortion.
The White House offered no explanations for the reshuffle, except that Blackburn and May's terms had expired in January. "We've decided to go ahead and appoint other individuals with different expertise and experience," said a spokeswoman. Professor Blackburn accused the president of stacking the council, a charge echoed by other scientists and politicians. "The American people deserve the right science, not right-wing ideology, on critical issues facing their health," said Massachusetts senator Ted Kennedy. ~ Washington Post, AP, Feb 28, AP
New publicity strategy for therapeutic cloning campaign
Scientists lobbying for therapeutic cloning are using a new argument to persuade politicians and the public to endorse the controversial procedure. Until recently they had been stressing the possibility of "miracle cures" for ailments like Parkinson's disease, Alzheimer's disease and juvenile diabetes if they could use laboratory-created embryos to create stem cells. But it has become apparent that clinical applications for embryonic stem cells are still many years away -- 10 years at the earliest. More importantly, intense lobbying has still failed to secure essential funding from the US government for programs which create and destroy embryos.
Although embryonic stem cell researchers still believe that cures will come, the Washington Post reports that "in moments of candour... many scientists concede that therapeutic cloning is far down the list of reasons they want to clone human embryos". They have now begun to highlight the embryo's potential for research, their focus shifting from making sick adults healthy to making healthy embyros sick. "Instead of making cloned embryos as a source of healthy stem cells for transplantation into patients, scientists are proposing to make cloned embryos that explicitly bear the genetic glitch or glitches at the root of a patient's disease," the Post says.
The disease highlighted by leading stem cell researchers like Ian Wilmut, the Scottish scientist who created Dolly the sheep, and Irving Weissman, of Stanford University, is motor neurone disease (also known as Lou Gehrig's disease). They envisage taking a normal human egg and creating a clone with a diseased cell from a patient. The cloned embryo would then produce nerve stem cells. Researchers could watch the disease develop and use the embryos to test drugs which might slow or prevent the gradual degeneration.
"This use of clones has been totally missed by the public but is of extreme importance to really understand the molecular basis of disease," "says Robert Lanza of Advanced Cell Technology, an American company which is developing uses for cloning.
In any case, as Ian Wilmut points out, cloning technology is still extremely inefficient. "Typically only 0-5% of cloned embryos become viable offspring, regardless of species, method of nuclear transfer, choice of donor cells, or species," he writes in the British Medical Journal. Offspring which do survive often have severe abnormalities. These abnormalities could also make cloned embryos useless for stem cell therapies as well. "In these circumstances," he says, "it would seem sensible for the first use of cells from cloned embryos to be in research". ~ Washington Post, Feb 23; BMJ.com, Feb 21
Dolly's creator backs cloned babies
The creator of Dolly the cloned sheep, Ian Wilmut, argues that it may be necessary to clone babies to prevent genetic diseases. But in his proposal, the babies would be clones of a diseased embryo, not of an adult. In an article in the New Scientist he says that "while I remain implacably opposed to reproductive cloning per se, I do envisage that producing cloned babies would be desirable in certain circumstances, such as to prevent genetic disease".
This would happen when a couple wishes to avoid passing on an inherited disease to their children. Using IVF, they could manufacture an embryo which would yield embryonic stem cells. Using genetic engineering techniques, a scientist could alter the offending gene and use the corrected stem cells to create a clone. "The resulting embryo would be the identical twin of the original one, but with the diseased gene corrected in every one of its cells. Although such a child would be a clone, it would be the clone of the new individual, not the clone of one of its parents."
Dr Wilmut seems also implacably opposed to restrictions on all variants of cloning -- except for the reproductive kind carried out by the Raelian cult and American fertility expert Dr Panos Zavos. "Cloning promises such benefits that it would be immoral not to do it," he says. ~ London Times, Feb 19; London Telegraph, Feb 19
Nitschke cooking up a "peaceful biscuit"
First a DIY suicide machine, now the "peaceful biscuit". Euthanasia activist Dr Philip Nitschke has revealed that he is working on a new way to help people kill themselves. "The idea is it will be something that can be made at home using two commonly obtained chemicals," he told the Bulletin. "it would be an enormous reassurance to the elderly folk of Australia if they knew they had a pill or biscuit at home which they could take when the time was right," he says. "The paradox is that it also means people will live longer because they don't have to fear losing the capacity to take more radical action." ~ Bulletin, Jan 28
The Bulletin's feature on euthanasia in Australia also listed a number of people who could go on trial for helping others to die:
- Tasmanian Stuart Godfrey, who helped his mother, former Tasmanian TV chef and author Elizabeth Godfrey, to commit suicide.
- Tasmanian Catherine Anne Pryor, who helped her 79-year-old father to commit suicide.
- Fred Thompson, from the central coast of NSW, who killed his wife who was suffering from multiple sclerosis.
- The 21 people who accompanied Nancy Crick, the Queensland woman advised by Dr Nitschke, when she committed suicide.
- Sydney doctor Andrew Hollo, a former director of the NSW Voluntary Euthanasia Society, who has been charged with administering a fatal dose of insulin to one of his patients.

Genetically modified athletes on the horizon
Scientists worry that gene therapy for increasing muscle strength for patients with muscular dystrophy could be used to create genetically enhanced athletes. Researchers at the University of Pennsylvania have found that gene therapy has helped rats to become 15 to 20 per cent stronger even without exercise. But lead researcher Lee Sweeney says that half of the email queries he receives about his work are from sportsmen.
"Gene doping" has already been banned under international sporting rules but it would be difficult to detect without a muscle biopsy. Gene therapy is still in its infancy and could be dangerous. Two patients treated with innovative gene therapy for "bubble boy syndrome" have developed leukaemia. It is also possible that muscles could become so strong that athletes' bones would break. ~ New Scientist, Feb 17
Costa Rican president wins prize for opposing cloning
The president of Costa Rica, Dr Abel Pacheco, has been awarded an international peace prize for his opposition to cloning. His country has led a campaign in the United Nations for a comprehensive ban on cloning. In his remarks at the dinner for the inaugural Kolbe Peace Prize, the president, a medical doctor, said that Costa Rica's "historic commitment to human dignity has moved us to propose to the United Nations the adoption of a comprehensive ban on all forms of human cloning. Human cloning, whether done with the purpose of creating identical copies of other human beings or to make scientific experiments, constitutes a grave breach of human dignity." ~ C-Fam, Feb 27
UK entrepreneur hawks human eggs on internet
A British businessman has set up a website offering eggs for potential parents, www.WomanNotIncluded.com. Clients will be able to scan a global database of donors, select one, and arrange for delivery of the eggs to an IVF clinic. The fees will include a £145 sign-up fee and between £600 and £1,200 for each match with a donor. The website's founder, John Gonzalez, says that this will be "the world's first comprehensive online provider of human eggs". He claims that his other website, www.ManNotIncluded.com, now has 9,000 registered sperm donors and has resulted in six births. ~ Scotsman, Feb 23
Embryo screening first for Melbourne
The first Australian baby to be screened to avoid a genetic mutation has been born in Melbourne after treatment at Monash IVF. Nathan Runciman's mother, Kerrie, has familial adenomatous polyposis, which can cause bowel cancer and kill patients in their 20s and 30s if left untreated. Her own colon was removed when she was 19.
Mrs Runciman, 33, decided to have a child when she learned of the existence of a test to determine whether her embryos would carry the gene. She produced eight embryos and five were carriers. Two non-carriers were implanted in her womb, and she became pregnant with Nathan. He is probably the first child to be screened for this disease.
The CEO of Monash IVF, Donna Howlett, says that her centre has produced 15 babies which have been tested for single gene disorders such as cystic fibrosis, Huntington's disease, Lesch-Nyhan syndrome, tuberous sclerosis and myotonic dystrophy. ~ Age, Feb 17
UK bioethicist backs infanticide
One of Britain's leading bioethicists has endorsed infanticide. John Harris, a professor at the University of Manchester and a member of the British Medical Association's ethics committee, was speaking at a public consultation into reproductive technologies. "I don't think infanticide is always unjustifiable," he said. "I don't think it is plausible to think that there is any moral change that occurs during the journey down the birth canal."
Professor Harris later explained his stand. "There is a very widespread and accepted practice of infanticide in most countries. We ought to be much more upfront about the ethics of all of this and ask ourselves the serious question: what do we really think is different between newborns and late foetuses." He acknowledged that this could lead to infanticide for cosmetic reasons, but said that the child's future was a matter for individual couples.
A spokeswoman for the BMA said that Professor Harris's views were his own and that the BMA was "utterly opposed" to infanticide. ~ London Telegraph, Jan 25
Starting life in a Petri dish may harm embryos
Mice born through IVF behave differently from normal mice according to researchers at the University of Pennsylvania. The scientists attributed greater anxiety and worse memory to the length of time that the embryos spent in culture media before implantation. Although they caution that these results are not directly applicable to human embryos, they "suggest that a special effort should be made to minimise the effect of culture on the human pre-implantation embryo".
These findings, published in the Proceedings of the National Academy of Sciences, appear to run counter to efforts by IVF doctors to reduce the number of multiple births. They are cultivating embyros for a longer time so that they can identify the best ones to transfer to a patient's womb. There is now a growing body of research that supports the view that the culture media for human embryos may cause or at least contribute to certain rare abnormalities. ~ BBC, Jan 27; PNAS, Feb 10
IVF families in the news
Some bizarre relationships created by assisted reproductive technology have featured in world news in the past few weeks:
- A 64-year-old Indian woman has given birth to a 1.75 kilo boy, making her one of the world's oldest mothers. Mrs Papathiammal Subramaniam, of Tamil Nadu, used an egg donated by a 30-year-old relative and her 74-year-old husband's sperm. The couple had had no children in their 47 years of marriage. ~ BBC, Feb 23
- An Israeli woman has given birth to twins from embryos created 12 years ago and kept in a freezer. She already has twins from the same batch of embryos who are now 12 years old. The previous record for frozen embryos is believed to be 7 years. ~ BBC, Feb 4
- A British woman, Carole Moore, has revealed that she gave birth to her stepbrother 10 years ago after acting as a surrogate for her 52-year-old mother, Maureen Knight. Mrs Knight was resigned to having no children from her third marriage, but her new husband was eager to have a child. Their son (or grandson) was conceived using a DIY insemination kit. "My school friends get a bit confused when I try and explain it," says Luke Knight. "But I feel really special because I am the only one I know who has two mums." Mr and Mrs Knight have now separated. ~ Mirror, Feb 12

The bioethicist as hero
Julian Savulescu, an Australian bioethicist working at Oxford University, has called upon his colleagues to be heroic and to stand firm on matters of principle when confronted by commercial or institutional pressures. In an editorial in the Journal of Medical Ethics, Dr Savulescu asks, "How can we as bioethicists make a difference if we are not heroes?" He calls upon his colleagues to support each other in difficult situations. "We need more solidarity and collegiality. We should be able to call on colleagues to support us, to write and act jointly for some moral cause. Bioethics organisations should not simply function to run conferences and other junkets but should serve as a resource for collective and effective action." ~ Journal of Medical Ethics, February
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