Tuesday, 25 October 2005 ·  Issue 181

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BioEdge 181: Kass farewells bioethics council with ageing report

IN THIS WEEK'S BioEDGE


bullet 
Kass farewells bioethics council with ageing report
      Huge increase demands ethical response
bullet 
A second look at PGD
      Embryos may be able to correct defects
bullet 
Financial links to drug use guidelines
      Many reviewers have links to manufacturers
bullet 
South Korea cloner opens stem cell library in US and UK
      Hwang uses Korean expertise to supply the world
bullet 
Foetal stem cells to be used to cure children
      Stanford to attempt curing rare brain disease
bullet 
IN BRIEF: do not resuscitate; patents; cosmetic surgery; animal liberation

TO OUR READERS:

BioEdge will not be issued on November 2 and November 8. The next issue will be November 15.

Kass farewells bioethics council with ageing report

Ageing is unpleasant, unwanted, and unprofitable. But the US will have to adjust to a large increase in its elderly in the coming decades and face up to many ethical challenges. So says the last report by the President's Council on Bioethics to be published under the stewardship of Leon Kass. In another eloquent, thoughtful document, Taking Care: Ethical Caregiving In Our Aging Society", the council warns of an unprecedented "mass geriatric society" and makes some recommendations for public policy. The report was hardly reported in the media, but deserves careful scrutiny because of the urgency of the problem and the sensitivity of its analysis. Kass's own hand is evident in its style and ethical sensitivity. Amongst the observations and suggestions are the following:
  • Between 2000 and 2050, the population of Americans between 45 and 64 will rise from 61 million to 85 million, but the population of 65s and over will grow from 34 to 79 million, with those 85 and over rising from 4 to 18 million.
  • Living longer will mean longer periods of chronic illness and dependency before death. "An unprecedented number of people will need long-term care, not just for months but for years".
  • America is facing an alarming shortage of care-givers because of smaller, more mobile and more fragmented families.
  • The report strongly opposes euthanasia and assisted suicide as antithetical to ethical caregiving for people with disability". "One cannot think wholeheartedly about how best to care for the life the patient has now if ending his or her life becomes, for us, always an eligible treatment option," it says.
  • The goal of care is not to prolong life as long as medically possible, but to benefit the life the patient still has.
  • Advance directives, or living wills, are flawed. Advanced proxy directives are more valuable.
  • A presidential commission on ageing, dementia and long-term care should be set up to recommend policies for innovation and reform.

In a column in the Washington Post, Kass summed up the message of the report: "Against our confidence in mastery and control, we need to remember that old age and dying are not problems to be solved but human experiences that must be faced. In the years ahead, we will be judged as a people by our willingness to stand by one another, not only in the rare event of natural disaster but also in the everyday care of those who gave us life and to whom we owe so much." ~ Washington Post, Sept 29; www.bioethics.gov   

A second look at PGD

A technique for detecting abnormalities in embryos may have been giving misleading results, according to papers presented at a Montreal conference of US and Canadian fertility doctors. In pre- implantation genetic diagnosis (PGD) one cell from an eight-cell embryo is extracted and examined for abnormalities. If an embryo appears to be healthy, it is implanted in the mother's womb. If not, it is usually discarded. Children born after the technique appear to be healthy, although there are no long-term studies.

However, it now appears that defective embryos are able to correct defects as they mature. One American experiment discovered that about half of the cells in "defective" embryos were normal by the blastocyst stage. This suggested two things to the fertility specialists. First, that defective embryos might be a viable source of embryonic stem cells, and second, that many embryos discarded as defective could have developed into healthy babies.

One initiative to emerge from the meeting is a US database to track the safety of PGD. American clinics are not presently required to report their data. ~ Nature, Oct 20   

Financial links to drug use guidelines

Many of the researchers and doctors who write the rules on prescribing drugs have financial connections to the manufacturers, according to an investigation by the leading journal Nature. More than one-third of authors declared that they had financial links to drug companies and more than 70% of clinical panels are affected. In one case, every member of a panel writing the guidelines for a treatment for anaemia for HIV patients had been paid by the drug's manufacturer. "The practice stinks," says Drummond Rennie, deputy editor of the Journal of the American Medical Association.

Although such links have been strongly criticised, the bodies which produce the guidelines counter that there simply aren't enough experts without potential conflicts of interest. The American Diabetes Association estimates that three-quarters of the members eligible to write clinical guidelines have conflicts of interest. ~ Nature, Oct 20   

South Korea cloner opens stem cell "library" in US and UK

Hwang Woo-Suk Korean cloning expert Hwang Woo-suk is to open a stem-cell "library" in Seoul with satellite laboratories in San Francisco and Oxford where human embryos can be cloned using his technology. The World Stem Cell Foundation will create about 100 stem cell lines annually for stem cell research.

One of the main attractions of Hwang's initiative is bypassing political, regulatory and financial barriers to embryonic stem cell research in the US. According to an article in the New England Journal of Medicine, a number of prominent US stem cell scientists are enthusiastic about the project because it will enable them to study diseases.

Many researchers believe that human embryonic stem cells may turn out to be even more valuable for studying the mechanisms of disease and for screening experimental drugs than for cell-based therapy, although it is their potential for providing replacements for dead or diseased cells and tissues that has captured the public imagination," writes Dr Susan Okie, a contributing editor of the NEJM.

An article in the on-line magazine Slate by David Plotz explains how South Korea has managed to become the cloning capital of the world without much funding or even a track record in biotech. The key to success is the extraordinary ability of Hwang himself, but some national characteristics help make his work more productive. Koreans are not "preoccupied with moral questions about the beginning of life". Despite an official ban on abortions, it has one of the highest abortion rates in the world.

Korean are "extremely open to medical self-improvement" -- they may have the highest cosmetic surgery rates in the world. The enormous pressure on Korean couples to have their own genetic children has also generated a large IVF industry with extremely high skills. (Plotz speaks of the "Chopstick Theory of Scientific Supremacy" -- that Koreans are skilled at manipulating embryos because of their handiness with chopsticks.) And Koreans work harder. The scientists who work in Hwang's laboratory have boring, repetitive jobs, but work seven days a week without holidays. ~ New England Journal of Medicine, Oct 20; Slate, Oct 19   

Foetal stem cells to be used to cure children

The US Food and Drug Administration has approved the first transplant of foetal stem cells to cure a rare and fatal children's disease. It says that doctors at Stanford University can begin tests on six children with Batten disease, a degenerative condition which leaves them blind, speechless and paralysed before they die.

The idea is to inject stem cells from aborted foetuses into the children's brains with the hope that they will graft to existing brain cells and replace the defective cells. It is a risky operation, but the alternative is certain death from the disease, say supporters of the experiment.

A company called Stem Cells Inc, which was founded by Irving Weissman, a leading figure in California stem cell research, is conducting the study. It obtains its foetal tissue from a non-profit organisation. The ultimate goal of the experiment is to use the same technique on patients suffering from other brain disorders. ~ AP, Oct 21   

IN BRIEF: DNR; patents; cosmetic surgery; animal liberation

Do not resuscitate: British stroke patients with "do not resuscitate" orders on their medical notes are seven times more likely to die in the first 30 days after their stroke than stroke patients without this order. The high mortality rate may be due to rationing of patients' access to stroke units, says an article in the International Journal for Quality in Health Care. ~ BMJ, Oct 22

Patents: Nearly a fifth of all human genes have been patented, according to a study by academics at the Massachusetts Institute of Technology. In an article in Science, they says that the situation could "increase the costs of genetic diagnostics, slow the development of new medicines, stifle academic research and discourage investment in downstream research and development." ~ The Age (Melbourne), Oct 15

Cosmetic surgery: Britain is thinking of toughening guidelines on cosmetic surgery after a steep rise in the number of botched operations by "cowboy" doctors in the UK and overseas. Plastic surgery is booming in the UK and high fees are forcing patients to seek help overseas. "One of the reasons many operations are cheap is that they don't offer any aftercare if things go wrong," says the president-elect of the British Association of Plastic Surgeons, Dr Douglas McGeorge. ~ London Telegraph, Oct 19

Animal liberation: Two members of a radical US animal rights group have been charged with multiple counts of animal cruelty in North Carolina. The two belong to People for the Ethical Treatment of Animals. Local shelters thought that they were taking animals to place them in new homes. Instead they allegedly gave them lethal injections and dumped the bodies in supermarket bins. The president of PETA, Ingrid Newkirk, defended their actions. ~ London Telegraphy, Oct 18   

 

  

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Australasian Bioethics Information
ISSN 1446-2117
Website:www.australasianbioethics.org
BioEdge editor: Michael Cook
New Zealand Contributing Editor: Carolyn Moynihan


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