Tuesday, 30 May 2006

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BioEdge 205: Engineers of synthetic life search for guidelines

THIS WEEK


bullet 
Engineers of synthetic life search for guidelines
      Lobby groups say scientists cannot be judge and jury
bullet 
Indian clinical trials will be ethical, say local doctors
      Burgeoning career opportunities, too
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Your genes can send you to the poorhouse
      Scottish researchers says poverty is in your DNA
bullet 
Kevorkian seeks parole
      Only a year to live, his lawyer says
bullet 
Stem cells becoming US election issue again
      Bush stands firm against embryonic stem cell funding
bullet 
Euthanasia harms doctors, too
      Study shows they find it distressing
bullet 
UK parents seeking perfect babies
      Babies aborted for minor defects
bullet 
IVF risk of pregnancy complication
      Placenta praevia far more common in IVF
bullet 
Something special for Father's Day
      Gay activist acquires a harem
bullet 
IN BRIEF: Korea; UK IVF

ENGINEERS OF SYNTHETIC LIFE SEARCH FOR GUIDELINES

Scientists working in the new field of synthetic biology have yielded to public pressure and deferred adopting a self-regulating code of conduct. Synthetic biology, which aims to engineer cells to make useful devices, is highly controversial because of its potential for creating bioweapons and environmental risks. A conference in Berkeley, California, last week featured a draft of guidelines for self-regulation. However, on the eve of the meeting, 35 groups, including Greenpeace International and GeneWatch UK issued a counterproposal calling on scientists to participate in public debate. "Scientists creating new life forms cannot be allowed to act as judge and jury," said Sue Mayer, director of GeneWatch.

Like other exciting new fields, synthetic biologists wax lyrical about the payoff from creating organisms which have been programmed at a genetic level. The benefits for medicine, agriculture, manufacturing and energy production could be huge. But what alarms many people is the possibility of bioterrorism. Theoretically, for instance, it would be possible to piece together the lethal smallpox virus. Even Scientific American has urged biotechnologists to be cautious. "Half a century ago, if recklessness, greed and unreasonable fear had somehow handicapped the development of integrated circuits, then the computing and communications revolution would have been snuffed out. Now is an equally pivotal moment for the future of biotechnology," said an editorial. ~ New Scientist, May 23; Scientific American, May 22   

INDIAN CLINICAL TRIALS WILL BE ETHICAL, SAY LOCAL DOCTORS

Indian doctors and scientists have dismissed fears by foreign observers that their country is being turned into a nation of guinea pigs for drug companies. A widely circulated article in Wired by Jennifer Kahn recently asserted that the worst offenders were, to her surprise, Indian drug companies. "The accountability is very well laid on paper," says Dr B.K. Rao, of Sir Ganga Ram Hospital in New Delhi. "Besides the ethics committees of hospitals which monitor the trials, there are international agencies like the FDA which have to finally approve the drug... The controls are so strict that if anything wrong is found happening, the drug is immediately rejected."

Dr Umakanta Sahoo, of Chiltern International, a clinical research group, says that Indian regulations ban foreign companies from conducting phase I trials. Volunteers benefit from Phase II, III and IV trials because they receive improved care and free drugs during the trial, he says.

The market for clinical trials in India is booming. One study estimates that it will rise from US$200 million next year to between $500 million and $1 billion in 2010. As a result there is a shortage of qualified research staff. Running clinical trials "is emerging as a very lucrative career option for bioscience, medical and pharma graduates," says Rajiv Verma, of the Institute of Clinical Research in New Delhi. ~ Rediff.com, May 29   

YOUR GENES CAN SEND YOU TO THE POORHOUSE

In recent years scientists have been tumbling over each other to announce the discovery of disease-causing genes for breast cancer, colon cancer, Huntington's, bubble boy disease and so on. Once detected, disease-bearing embryos or foetuses can be treated or, more often, destroyed. Now researchers in Scotland claim to have found a "poverty gene" which causes people from deprived areas to age rapidly, be unhealthy and shirk work. They suspect that a hyperactive immune system floods the brain with chemicals which suppress a desire for self-advancement.

Faulty evolution is at work, apparently. An active immune system helps to keep children healthy, but in later life it causes additional stress on the body. "If you look at a person from the East End of Glasgow aged 55," says Dr Chris Packard, of the Glasgow Centre for Population Health, " they may look far closer to 65 or 70, while those from a more affluent area of the same age will probably be far closer to their real age."

Other experts have dismissed the news. Allyson Pollock, of the Centre for International Public Health Policy, warned that linking poverty to genetics could lead to the notion that the poor were inferior. "Poverty is not a genetic issue, it is an economic issue," she said. "If you go down that route you may end up with eugenics, and that is extremely worrying." ~ Scotland on Sunday, May 21   

KEVORKIAN SEEKS PAROLE

America's Dr Death, Jack Kevorkian, celebrated his 78th birthday on May 26 in jail. It seems that he has less than a year to live. According to his lawyer, Mayer Morganroth, Dr Kevorkian suffers from high blood pressure, cardiovascular disease, temporal arthritis, active Hepatitis C, peripheral arteritis, adrenal insufficiency, chronic pulmonary obstruction disease, hypertensive cardiovascular disease, cataracts, diplopia, vertigo, dysphagia, headaches, left ventricular hypertrophy, osteoporosis, ataxia and eschemia. He also fell recently, injuring his wrist and breaking two ribs. Because of his deteriorating health, Mr Morganroth has asked the Michigan governor to grant his client early parole. Under his present sentence, Kervorkian will only be eligible for parole in June 2007.

Furthermore, after several years in a Michigan jail, Kevorkian may be having second thoughts about assisted suicide, which he participated in more than 100 times. "He did what he did and it brought it to public awareness," Mr Morganroth declared. "He now realises that having performed it when it was against the law wasn't the, probably, appropriate way go to about it... What he should have done was work towards its legalisation verbally."

Kevorkian remains a hero for euthanasia activists. A Hollywood producer is working on a film of his life, "You Don't Know Jack". And a new book, "Between the Dying and the Dead," purports to explore the many facets and talents of Dr Jack Kevorkian as an artist, writer, pianist, composer and sensitive human being". ~ ABC News, May 26; press release   

STEM CELLS BECOMING US ELECTION ISSUE AGAIN

November elections in the US could spark debates over stem cell regulations in the coming months. Thirty-three seats in the Senate and 435 seats in the House will be contested. Politicians' views on stem cells will help to decide some of these, says Nature. According to Washington scuttlebutt, the Senate may vote on a package of three stem cell bills during the (northern) summer -- but details are still sketchy.

Any effort to revive a push for funding for embryonic stem cells has to contend with President Bush. He has stubbornly stuck to his policy of threatening to veto any bill which would "take us across a critical ethical line by creating new incentives for the ongoing destruction of emerging human life." ~ Nature, May 25; National Review Online, May 25   

EUTHANASIA HARMS DOCTORS, TOO

Doctors who participate in physician-assisted suicide are scarred emotionally and psychologically by the experience, according to a study by a doctor opposed to the practice. Kenneth R. Stevens Jr, of the Physicians for Compassionate Care Education Foundation, says that these side-effects are often overlooked. "Doctors must take responsibility for causing the patient's death," he writes. "There is a huge burden on conscience, tangled emotions and a large psychological toll." He also claims that some doctors feel pressured by their patients and others to participate.

Dr Stevens based his observations on reports in the media and medical journals. One comment by Pieter Admiraal, a leading figure in Dutch euthanasia, sums up his colleagues' comments: "You will never get accustomed to killing somebody. We are not trained to kill. With euthanasia, your nightmare comes true." ~ PCCEF website, Apr 10   

UK PARENTS SEEKING PERFECT BABIES

British children are being aborted in record numbers for relatively minor conditions, according to recent statistics, confirming fears that more and more parents want only "perfect babies". In the UK, abortions can be performed up to birth if a child has a "serious handicap", a rubbery provision which does not exist in other countries. It was intended to spare women from the trauma of giving birth to babies who were likely to die in their infancy, but it is now being used for conditions like club foot and cleft palate.

According to the London Times, between 1996 and 2004, 20 babies were aborted in advanced pregnancy because of club foot and another four because they had webbed fingers or an extra digit. All these condition are easily corrected. One doctor in the north of England discovered that an abortion had been performed in his hospital because a child was missing a hand. "The father did not want the pregnancy to proceed because of his perception that the child would not be able to do all the usual things like sport," he said.

The problem is even more acute with Down's syndrome, according to the London Telegraph. Since 2003, the National Health Service has offered a screening service to all 760,000 women in the UK who fall pregnant. As a result, 62% of Down's syndrome children are detected in the womb and 92% of these are aborted. This is a case of "overt eugenics", says Nuala Scarisbrick, of the lobby group Life. "There are human rights for everybody unless you are disabled in some way."

Furthermore, the incidence of Down's syndrome is rising, because the number of women who have children in their 40 has doubled over the last ten years. Abortions for the condition have reached record levels. The Down's Syndrome Association says that despite the fact that great progress has been made in prenatal medicine, many doctors are still ignorant of what life is like for handicapped children and their families. ~ London Telegraph, May 21; London Sunday Times, May 28   

IVF RISK OF PREGNANCY COMPLICATION

Norwegian researchers say that there is a five-fold increase in risk of a dangerous complication of pregnancy in women who have conceived a child through IVF. In a study of 845,300 pregnancies they found that the risk of placenta praevia, a condition in which the placenta covers part or all of the cervix, blocking a baby's passage into the birth canal, rose from about 3 in 1,000 for normal pregnancies to 16 in 1,000 for IVF pregnancies. And for women who had two pregnancies, one natural and one using reproductive technology, the risk rose three-fold, from 7 in 1,000 to 20 in 1,000.

The cause of the increased risk for the potentially fatal condition is not clear. IVF may trigger contractions which lead to embryos implanting lower down the uterus than in natural conceptions. Or doctors may position the embryo lower down in order to improve implantation rates. The researchers, from St Olav's University Hospital in Trondheim, suggest that IVF clinics should record the position of every embryo they implant. ~ BBC, May 24   

SOMETHING SPECIAL FOR FATHER'S DAY

Paul Van Reyk presiding at a Father's Day dinner Gay activist and accredited lifestyle coach Paul Van Reyk has been featured on Australian TV as a sort of stud for single women and lesbians. More than 20 years ago he began his progenitive career by fathering a child for a single woman whom he married, but only to give the child legal protection. It was, in part, a political statement. "It seemed wrong to me that gay men and woman were excluded from having children," he says.

Then other friends sought his help and now Mr Van Reyk has had six children by five different mothers. He may even have another half dozen children, but he is not sure because he agreed not to inquire about whether these women had successfully conceived. Although he is not involved in his children's lives on a day-to-day basis, he feels comfortable with his role. He even celebrates Father's Day rather like a polygamous patriarch presiding over his brood.

The casualness of his sexual engagements has at least one drawback, the possibility of unwitting incest. His first child Mary even jokes with his second, Raj, that he should be careful about kissing a possible sibling. ~ ABC Australian Story, May 29   

IN BRIEF: Korea; IVF twins

KOREA: Despite the Hwang debacle, the South Korean government is still determined to ensure that it becomes one of the world's top three powerhouses in stem cell biotechnology by 2015. This week it signed off on a plan to spend US$454 million on stem cell research. This will cover both adult and embryonic stem cells, along with strengthening ethical standards, said an official at the Ministry of Science and Technology. ~ Korea Times, May 29

IVF TWINS: A British couple has had their second IVF twin 16 years after the birth of the first. The embryos for Jane and Alan Davis were created in 1989 and Emma was born in that year. The couple tried to have another child unsuccessfully several times. Finally, in 2003 Jane gave birth to another girl, Niamh, who had been in a freezer for 16 years before being implanted. ~ icSurryOnline, May 24   

 

  

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Australasian Bioethics Information
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BioEdge editor: Michael Cook
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