The United States, like other nations, is facing a huge shortage of organs. At the moment, there are 92, 400 Americans waiting for organs -- mostly kidneys -- but only 14,500 people donated them last year. People are waiting up to five years for a match -- longer than the median survival rate in many cases. Bad as this news is, prospects for the future look worse. One result of the so-called obesity epidemic is that the number of patients with kidney failure as a result of diabetes and high blood pressure will probably soar. The crisis is already provoking discussion of radical solutions. Some of these were raised at the World Transplant Congress in Boston last month.
Since most donors are dead, an obvious solution is to enlarge the pool of dead people. Most potential donors and their relatives believe that doctors take organs only from brain-dead people. However, redefining death as what happens when your heart beat stops, not when your brain waves flatline, will increase the number of American bodies available for organ harvesting by 22,000. This is an option backed by the US Institute of Medicine in a report earlier this year. Strong support from the British government has increased the number of "donors after cardiac death" by six-fold in the last 15 years. Not all doctors agree with this. Like Lazarus, some patients do recover after their breathing and heartbeat have stopped. However, more and more hospitals are using this definition -- and even expanding it. Just to make sure that the patient is really dead, transplant surgeons used to wait 10 minutes. This interval is dropping to 5 minutes, and three American centres are using a two-minute interval.
There are other options, too -- all highly controversial. The Institute of Medicine baulked at paying organ donors, but a number of bioethicists, libertarians and free-market conservatives contend that this is the only way to meet the shortage. "I resisted all market mechanisms because of the risk of injustice," says Robert Veach, of Georgetown University. "I think we've waited long enough. There are too many people dying. I think it's time to begin limited experiments with cash payments." Sally Satel, a doctor and well- known conservative pundit, wrote in the New York Times earlier this year that repugnance at selling body parts is outdated. Markets for human eggs, sperm and surrogate mothers already exist and are no longer controversial, she argued. What's different about organs?
Other contentious ideas have also been mooted. These include classifying patients in permanent vegetative states or unconscious comas as dead, including high-risk donors such as intravenous drug users or homosexuals, and allowing committed donors to go higher on waiting lists. Some patients cut waiting times themselves by buying organs on the black market in developing countries. With the gap between patients and donors widening, there will be increasing pressure to implement some of these schemes, however far-fetched they now seem. ~
New Scientist, Aug 4;
New York Times, May 15;
Lancet, Aug 12 (reg req
CAN WOMEN DONATE THEIR EGGS FOR RESEARCH ETHICALLY?
As embryonic stem cell research comes under closer scrutiny in the US, UK and Australia, stem cell scientists are examining the ethics of egg procurement. Since most biologists doubt that an embryo is a human person, the possibility of exploiting women is the only major ethical issue which divides them. One of the misdemeanours of disgraced Korean stem cell scientist Hwang Woo-suk which most disgusted other scientists was that he forced some of his junior colleagues to donate eggs and bought other eggs illegally.
With this in mind, and no doubt its political battles as well, a task force of the International Society for Stem Cell Research has issued draft guidelines. These insist on informed consent for this uncomfortable and potentially fatal procedure. But they leave the door open to remunerating women for the time, discomfort and trouble involved in egg donation. The chair of the task force, Insoo Hyun, of Case Western Reserve University, argues in the leading journal Nature that local ethics committees will act responsibly in setting compensation at a level which constitutes fair compensation, but not an inducement.
Nature's editorial in the same issue is sceptical of Dr Hyun's confidence in ethics committees and points out that the health risks of ovarian stimulation are still not clear. There is some evidence that the fertility drugs used in IVF and egg donation pose long-term risks of cancer. Researchers say that longitudinal studies are needed, as the cancers may not appear until women are in their 50s or 60s. However, as Nature journalist Helen Pearson remarks, "it's unclear who will drive the effort, particularly when private fertility clinics may have little interest in finding out the potential risks of the drugs they use."
Ironically, in the week of Nature's focus on the dangers of egg donation, a healthy 37-year-old woman in the UK died after her eggs were retrieved for IVF treatment. Nita Solanki appears to have succumbed to internal bleeding and renal failure. Her death follows the fatal IVF treatment given to a 33-year-old woman in the UK last year. Temilola Akinbolagbe died of a heart attack caused by ovarian hyperstimulation syndrome (OHSS). IVF is generally regarded as safe, but OHSS does affect about 6% of women to some degree. ~
London Times, Aug 11;
Nature, Aug 10
JAPANESE SCIENTISTS TURN ADULT CELLS INTO EMBRYONIC CELLS
Japanese scientists may be on the track of one of the great dreams of regenerative medicine: making an adult cell revert into an embryonic stem cell. If their results are confirmed and if the technique also works with human cells, it could defuse the bitter ethical and political debate about embryo research. Shinya Yamanaka and Kazutoshi Takahashi, of Kyoto University, found that four factors, or genes, turned the adult cells into cells which behave like embryonic stem cells. These passed the basic ID test: when injected under the skin of healthy mice, they formed teratomas, or tumours from the three germ layers of the body. Up to now it has been thought impossible to create an embryonic stem cell without resorting to cloning.
Yamanaka and Takahashi's work is still preliminary, of course. An American cloning expert, Robert Lanza, says that the experiment was exciting, but inconclusive. It required serious genetic modification of the cells, which could lead to cancers at some stage, he cautioned. ~
Yomiuri Shimbun, Aug 12
BAN HYBRIDS, SAYS SCOTTISH THINK TANK
Mixing animal and human material to create hybrids should be banned, says the Scottish Council on Human Bioethics. ""Most people are not aware that these kinds of experiments have been taking place in the UK and find it deeply offensive," says Dr Calum MacKellar, the SCHB's director of research. "Parliament should follow France and Germany and prohibit the creation of animal-human hybrid embryos." However, the scientist who cloned Dolly robustly defended the use of hybrid embryos. "By casting a negative light on a number of important research opportunities, this report may limit medical progress," says Dr Ian Wilmut.
Hybrids have been created in several experiments around the world over the past few years, but the SCBH questions their scientific merit. It warns that creating embryonic stem cells from the enucleated eggs of cows or rabbits filled with genetic material from a human cell poses "profound medical risks" and, in any case, would yield hard-to-interpret results.
Hybrids are far from fanciful, as they are a very practical solution proposed by some stem cell scientists who lament the shortage of human eggs for their research. In the UK, the government will probably propose new regulations on animal-human chimeras in October. And in Australia, the government is still agonising over whether to accept the recommendations of its Lockhart Review, which recommended legalising both therapeutic cloning and human-animal hybrids. ~
The Scotsman, Aug 8;
Scottish Council on Human Bioethics website
DRUG SHORTAGE SLOWS BELGIAN EUTHANASIA
While doctors in the US worry about a shortage of flu vaccines in next winter, Belgian doctors are fretting about a shortage of a different drug Pentothal, the lethal concoction used in Belgium's legal euthanasia cases. Because US pharmaceutical giant Abbott passed the production of the drug to its spin-off company Hospira, there have been some bureaucratic delays. Now it appears that it could be three months before supplies are restored. On average there are about 30 registered euthanasia deaths in Belgium every month, all using Pentothal. According to Expatica News, another 30 are unregistered. "That means," says Expatica, "that up to 180 people who wish to die a dignified death in coming months could denied the chance, unless normal Pentothal supplies can be restored or the drug is supplied from abroad." ~
Expatica, Aug 9
MODERN MUMMIES DRAW CROWDS AND CRITICISM
The fiercely competitive industry of exhibiting skinless, mummified human bodies in grotesque poses at commercial exhibitions hit a speed bump last month. The Chinese government banned the purchase or sale of human bodies and restricted the import or export of human specimens, unless they are for research. This could affect the fortunes of Premier Exhibitions, an American company which imports preserved bodies from China for its shows around the world. It is competing with the exhibitions pioneered by Dr Gunther von Hagens whose specimens have drawn 20 million people.
Public interest in the grotesque shows has apparently spurred a murky mini-industry in China. The bodies displayed by Premier Exhibitions are created by Dalian Medical University of Plastination Laboratories, according to its website. Where the bodies come from remains unclear despite protestations from Premier Exhibitions that it uses only unclaimed Chinese bodies given to medical schools by police. Human rights groups allege that the bodies of executed prisoners and the mentally ill are being used as well.
According to the New York Times, exhibitions featuring preserved bodies are amongst the most popular attractions at American science and natural history museums at the moment. "These are blockbuster shows," says Robert West, an analyst of the museum exhibition business. "We haven't seen anything like this since the robotic dinosaurs in the 1980s." Nonetheless, the exhibits have also attracted bilious criticism. Von Hagens says that he wants to "democratise anatomy", but his critics say that his shows are tasteless, disrespectful, and morbid. His exhibit, for instance, includes the body of a woman who died while eight months pregnant. She is posed like a reclining classical nude with her unborn foetus exposed. ~
New York Times, Aug 8
IN BRIEF: right to live; Iranian clones; research fraud in China
RIGHT TO LIVE CASE: A terminally-ill British man has lost his legal battle to ensure that he will receive nutrition and water when he is close to death. Leslie Burke, 46, has a degenerative brain condition and fears that he will be refused artificial nutrition and hydration when his condition worsens. The Court of Appeal in London ruled against him last year and now the European Court of Human Rights in Strasbourg has also declined his appeal. The Court said that it interpreted the UK law as being in favour of prolonging life whenever possible. ~
Scotsman, Aug 8
IRANIAN CLONES: Along with a healthy armaments industry, Iran is trying to develop its skills in animal cloning. A team at the Isfahan Royan Institute in Teheran has reported that it created the nation's first cloned lamb, although it died of respiratory problems shortly after birth. "We learned a lot about cloning during the experiment. It made us more hopeful about further cases," says Dr Morteza Hosseini.
AP, Aug 10
RESEARCH FRAUD IN CHINA: Although China's investment in life sciences has quintupled over the past five years to US$1.6 billion, ethical standards have not kept pace. More than 10 cases of misconduct have surfaced in the past year in fields ranging from information technology to biomedical research. The problem appears to be worst in the life sciences. The Ministry of Science and Technology now plans to set up an independent agency to monitor the research projects which it is funding. ~
Nature Medicine, August.