BioEdge 225 -- Tuesday, 31 October 2006

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BioEdge 225: Late motherhood may impair daughters' fertility

THIS WEEK


bullet 
Later motherhood may impair daughters' fertility
      Concern over intergenerational effects
bullet 
ASRM conference a fertile source of news
      Clown, mobile phones and autism
bullet 
Australian report splits on cloning
      Senate committee releases report
bullet 
TV stem cell ads could sway elections
      Michael J. Fox backs therapeutic cloning in ad
bullet 
Adult stem cells create mini liver
      But peer review still needed
bullet 
Taiwanese devotion
      Elderly couple care for daughter for 53 years
bullet 
Hwang's mammoth expenses
      Disgraced researcher has day in court
bullet 
Animal rights and the Holocaust
      Animal liberation "classic" seeks to link two calamities
bullet 
Oregon changes name of "physician assisted suicide"
      Under pressure from euthanasia lobby
bullet 
IN BRIEF: Kass, Singapore, custody, euthanasia

LATER MOTHERHOOD MAY IMPAIR DAUGHTERS' FERTILITY

The American Society for Reproductive Medicine has been holding its annual meeting in New Orleans -- always a reliable source of choke- on-your-Cheerios articles for newspapers around the world. This year the journal Nature even dispatched a reporter, Helen Pearson, who blogged her way through the "strange stuff that doctors do with embryos" throughout the week.

The most widely reported news from this year's conference was that women who wait until later in life to have children may risk damaging the fertility of their daughters. Although the study at an IVF clinic in Atlanta involved only 74 women, it raises the troubling possibility that the trend of women waiting until their late 30s to conceive may increase the infertility of the next generation.

"A mother's reproductive age is important not only for herself, but it will determine to a certain extent the chances of her daughter or daughters being infertile," said Dr Peter Nagy, of Reproductive Biology Associates. "When we are treating patients close to the age of 40, we are helping them get babies but, at the same time, these children will have a higher risk of becoming infertility patients."

The study found that women who became pregnant at the fertility clinic had slightly younger parents, with fathers aged 28.2 and mothers aged 25.7. Women who failed to become pregnant had parents who were on average 31.9 and 28.2. Women who failed to conceive were born when their mothers were about five years closer to the menopause. ~ Guardian, Oct 25   

ASRM CONFERENCE A FERTILE SOURCE OF NEWS

Here are a few more highlights from the New Orleans meeting:
Fifteen minutes watching a medical clown after an IVF cycle bumps pregnancy rates up from 20% to 36%, according to an Israeli doctor. Shevach Friedler, who is also a trained mime, says that dressing like a chef works better than wearing a red nose. ~
Nature newsblog, Oct 24

  • The president-elect of the ASRM, Dr David Adamson, said that British women who donate eggs to infertile couples should be financially rewarded for their efforts. Californian students are being offered US$10,000 for their eggs, while in Britain, only altruistic donations are allowed. "Why should we be surprised that money is a motivator? Money motivates people for most things," he said. ~ London Telegraph, Oct 27

  • Children born to couples who have undergone IVF are more likely to be diagnosed with autism, cancer and other disorders such as cerebral palsy and mental retardation, said researchers from Guy's and St Thomas's Hospital in London. Compared to the general population, the risk of autism in IVF births is four times as high. ~ Guardian, Oct 26

  • Four out of five women who have their eggs frozen at IVF clinics would consider using them to become single mothers, according to a small survey by a New York IVF clinic. "A number of women said they were interested in egg-freezing to take the pressure off the search for relationships," the researchers said. "Cryo-preservation meant the freedom to wait, and to not settle for a mate because they were in a rush to conceive." However, egg freezing is still not reliable, unlike sperm freezing, as eggs are larger and far more fragile. ~ London Times, Oct 27

  • IVF may skew the sex ratio significantly, according to a report by the Montefiore Medical Center in New York. Normally just over 51% of American newborns are boys and 49% are girls. However researchers found that only 41% of babies born in their clinic after IVF were boys and 59% were girls. They speculated that the stress of IVF might prevent male embryos from implanting or surviving. ~ Nature newsblog, Oct 26

  • An American doctor has warned that mobile phones "could be having a devastating effect on fertility". Dr Ashok Agarwal said that men who used a mobile phone for more than four hours a day have lower sperm counts and produce sperm of poorer quality than those who use them infrequently or not at all. Other experts questioned his findings, saying that other factors could be at work. ~ London Telegraph, Oct 25   

    AUSTRALIAN REPORT SPLITS ON CLONING

    Another report on the legalisation of therapeutic cloning for the Australian Parliament, written this time by a Senate committee, has split on the issue. By a vote of 5 to 3, a committee backed a private member's bill which will be decided on a conscience vote. The majority basically endorsed all the recommendations of last December's Lockhart Review. These include, either explicitly or implicitly, therapeutic cloning, hybrid embryos, creating embryos with genetic material from more than two people, the use of surplus IVF embryos, a new definition of a human embryo, and the possibility of harvesting eggs from cadavers or aborted female foetuses.

    The Australian newspaper predicts that the issue will be decided by a close vote -- about 55 per cent for, 45 per cent against -- perhaps as early as next week. There has been intense lobbying for and against the bill. ~ Australian, Oct 31   

    TV STEM CELL ADS COULD SWAY ELECTIONS

    Michael J. Fox More and more American celebrities are weighing into the stem cell debate as election day draws closer on November 7. In Missouri, St Louis Cardinals pitcher Jeff Suppan starred in an advertisement aired during Game 4 of baseball's World Series. He was expressing his opposition to an amendment to the Missouri constitution which would allow therapeutic cloning. Joining him were former Rams quarterback Kurt Warner, Mike Sweeney of the Kansas City Royals, actress Patricia Heaton and actor Jim Caviezel. In the ad, Suppan says, "Amendment 2 claims it bans human cloning, but in the 2,000 words you don't read, it makes cloning a constitutional right. Don't be deceived."

    Suppan's ad was a response to a powerful and controversial 30-second spot featuring actor Michael J. Fox, who has early-onset Parkinson's disease and endorses embryonic stem cell research as a way of finding a cure. It is painful to watch Fox make his point as his head and limbs jerk spasmodically. "Senator Talent [the Republican incumbent] even wanted to criminalize the science that gives us the chance for hope," he alleges. He tells voters that "what you do in Missouri matters to millions of Americans. Americans like me."

    The controversial commercial, which was aired in several states, prompted right-wing radio attack dog Rush Limbaugh to ridicule Fox, claiming that he had gone off his medication or was acting in order to generate more sympathy for the cause. Limbaugh later apologised.

    In some states, voters' views on stem cell research could determine the outcome of the election. Missouri is one of these, with Michael J. Fox supporting Democrat Claire McCaskill, who is seeking to unseat incumbent Governor James M. Talent. In Wisconsin, the incumbent governor, Jim Doyle, has made therapeutic cloning a centrepiece of his campaign. He is telling voters that stem cell research will bring medical cures for dread diseases and an economic boom for his state. His opponent, Republican Mark Green, opposes embryo research but supports the use of adult stem cells.   

    ADULT STEM CELLS CREATE MINI LIVER

    British scientists claim to have grown the world's first artificial liver by using cord blood stem cells. The technique, they say, could be used to test drugs within two years, to repair damaged livers within five years and to grow livers for transplant within 15 years.

    Researchers at Newcastle University took blood cells from an umbilical cord. Then they cultivated them in a "bioreactor" -- a machine developed by NASA to mimic the effects of weightlessness. This allows the cells to multiply more quickly than usual. Various hormones and chemicals coaxed the stem cells into turning into liver tissue. So far, tiny pieces of tissue, less than an inch in diameter have been created.

    Ethically, the advantage of this line of research is that it does not involve the destruction of embryos. While it is good news both for opponents of therapeutic cloning and of testing drugs on animals, the research has not been peer-reviewed. ~ Medical News Today, Oct 31   

    TAIWANESE DEVOTION

    A Taiwanese couple in their 80s who have been caring for their blind and paralyzed daughter for 53 years have insisted that they would never consider euthanasia. No matter how hard their job is, Lin Ting-chih, 81, and her husband Chiang Yu-chao, 82, plan to soldier on. "We will not let someone else look after her," says the wife. We will care for her ourselves and eventually see who is going to fall first."

    Their daughter, Chiang Yu-chao, became paralysed shortly after her first birthday and became blind at six. She has never been exposed to sunlight. Her bones have become so brittle that the couple must take extreme care in turning her and cleaning her. Although there is a movement in Taiwan for euthanasia in such cases, Lin says: "No way. I will not let that happen to my daughter." ~ CNA, Oct 26   

    HWANG'S MAMMOTH EXPENSES

    With a nuclear-armed maniac rattling his missiles only a few miles away, South Koreans are no longer as focused on their stem cell debacle as they were a few months ago. But disgraced researcher Hwang Woo-suk has been in court this month telling his side of the sad story of faked human clones and browbeaten egg donors. Hwang still insists that researchers at his lab deceived him.

    As for the US$2 million that appear to have disappeared, he has some intriguing explanations. "Some of the money was spent in contacting the Russian mafia as we tried to clone mammoths," he told the court. But you can't say that [on the books], so we expensed it as money for cows for experiments." There is some confusion about what Hwang actually meant. Korean media say that he had to pay "travel taxes" to Russian gangsters on his quest for mammoth cells. ~ Baltimore Sun, Oct 28; Chosun Ilbo, Oct 27   

    ANIMAL RIGHTS AND THE HOLOCAUST

    Efforts of radical animal rights activists to assert a moral equivalence between the slaughter of animals and the Jewish Holocaust continue. The book Eternal Treblinka, by Charles Patterson, is being published in Japanese next year. It has also been published in English, French, Spanish, Portuguese, German and Hebrew. The book's title is taken from a comment by Nobel laureate Isaac Bashevis Singer, "In relation to [animals], all people are Nazis; for the animals, it is an eternal Treblinka."

    Eternal Treblinka examines the common roots of animal and human oppression and the similarities between how the Nazis treated their victims and how modern society treats the animals it slaughters for food. The first part describes the emergence of humans as the "master species" and how they came to dominate the earth and its other inhabitants. The second part examines the industrialisation of slaughter of both animals and humans in modern times. The last part profiles Jewish and German animal advocates whose links to the Holocaust prompted them to get involved in animal liberation advocacy. ~ Press release   

    OREGON CHANGES NAME OF "PHYSICIAN ASSISTED SUICIDE"

    Just as cloning has been rebadged as Somatic Cell Nuclear Transfer to shake off its negative connotations, Oregon has decided to rename physician assisted suicide". Its official name is now "physician- assisted death". Compassion & Choices, a euthanasia lobby group, suggested the change to Oregon's Department of Human Services, to be more consistent with the wording of the legislation which allows it. Polls show that people are more likely to approve legalising the practice when the word "suicide" is not used.

    Kathryn Tucker, of Compassion & Choices, says "This will be a sea change because how you speak of things strongly influences how you think of them." Gayle Atteberry, of Oregon Right to Life, criticised the move. "They have changed it to a euphemism to make it more palatable," she said. "Do they think it is going to make it easier for people to kill themselves?" ~ Salem Statesman Journal, Oct 17; American Medical News, Nov 6   

    IN BRIEF: Kass, Singapore, custody, euthanasia

    Kass: Just in time for Halloween Dr Leon Kass, the former chairman of the US President's Council on Bioethics, has been nominated as one of the Thirteen Scariest People in America by the progressive website AlterNet. Kass is "an intelligent, articulate and passionate guy", writes Clive Thompson, but his world view is "so medieval it would have embarrassed C.S. Lewis". His baneful influence has ensured that the US will not have a "big, sprawling debate on stem- cell research". ~ AlterNet, Oct 31

    Singapore: The National University of Singapore has opened a Centre for Biomedical Ethics which will focus on the stem cell research which the government hopes will become a major income spinner. The centre, the only one of its kind in Southeast Asia, plans to organise regional bioethics seminars to share its expertise. Its British head, Professor Alastair Campbell, is a former president of the International Society of Bioethics.

    Custody: A bizarre custody and surrogacy case has become even more complicated after a decision by the Utah Supreme Court. A Canadian man living in Las Vegas, Arturo Nuosci, paid Rachel Sullivan to be a surrogate mother for his child. However, when he was jailed for (unrelated) fraud, Sullivan relinquished her parental rights and gave the child to a Utah couple, Matt and Toni Worthington for adoption. Then she asked for the child back. The latest court ruling returns the child, who is now two years old, to Nuosci and Sullivan, although they are hardly a "couple". The case now goes back to the courts for a decision on the toddler's future, as in other custody disputes between biological parents. ~ AP, Oct 28

    Euthanasia: A French court has convicted an 80-year-old mother of murdering her disabled daughter, but gave her only a two-year suspended sentence. Leonie Crevel was the only carer for 42-year-old Florence. In July 2004 she tied a rope around her daughter's neck and pushed her off the bed. The prosecutor had asked for a five-year suspended sentence. "This was not euthanasia," said Delphine Miennel. "Florence had the right to live, even if she was heavily disabled. Florence never asked for that her suffering be brought to an end." ~ AP, Oct 24   

      

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    Australasian Bioethics Information
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    BioEdge editor: Michael Cook
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