Opponents of cloning human embryos are licking their wounds after last week's US election. Although the issue was just a straw in the gale which blew away the Republican majority in Congress, it has reshaped the politics of American bioethics. Throughout his administration President Bush has been adamant that he will not loosen restrictions on embryonic stem cell research. Now its supporters in the Senate appear to have one vote more than they need to override his veto. In the House of Representatives, however, supporters still appear to be about 30 votes short of that mark.
With Iraq and terrorism uppermost in voters' minds, it is difficult to discern what they feel about a boutique issue like therapeutic cloning, or, to use the woollier term preferred by supporters, somatic cell nuclear transfer. Six Democratic senatorial candidates who clearly supported it were victorious. Three governors who campaigned vigorously in favour of it won. But in the House, the results were less clear. Of 15 races in which the issue was prominent, eight supporters won, and seven lost. And even in the Senate, the results were not a straightforward endorsement of cloning. One of its most outspoken opponents, Rick Santorum, of Pennsylvania, was defeated by another opponent, Bob Casey Jr. So the election was far from being a ringing endorsement of the demands of scientists and patient advocacy groups.
Only in the state of Missouri did voters have a chance to deliver an unequivocal verdict on cloning. They had been asked to decide whether to support an amendment to the state constitution to legalise it and bulletproof it from legislative interference. In the end, they did, but only by 51% to 49%. Opponents of what they described as a "clone and kill amendment" whittled away a 2 to 1 lead earlier in the year to a margin of 47,000 votes, even though they were outspent by at least 10 to 1. Is the message that voters want cures at any cost, or that bottomless pockets are needed to secure their votes?
However, the election has certainly delivered more state funding for stem cell researchers, even if the Federal purse stays closed. New York's governor-elect Eliot Spitzer has promised US$1 billion for stem cell research. Wisconsin's governor Jim Doyle, who cruised back into office after making stem cell research a major plank in his campaign has promised significant support. Smaller initiatives are likely elsewhere.
Slate's canny observer of bioethical issues, William Saletan, observed that the 2006 election shows that biotechnology is becoming another major campaign issue for Americans, along with national security, the economy and the culture wars. "Hold on to your hats," he writes. "A new kind of issue has arrived. It's moral, it's economic, and it's life and death. Biotechnology is here to stay, even if humanity, as we know it, isn't." (For analysis from the editor of BioEdge, see his article in MercatorNet, "Health trumps ethics in mid-term elections".) ~ Slate, Nov 11; New Scientist, Nov 9; blog.bioethics.net, Nov 10
ISRAEL'S COUNTDOWN TO DEATH FOR THE TERMINALLY ILL
On December 15, a technology-driven advance directive for dying patients will come into effect in Israel. People will be able to record their wishes on how to be treated if they are terminally ill on a computerised national register accessible by all health funds and hospitals. They will be able to specify that they do not want to placed on a respirator.
The novel feature of this system, which was approved by the Knesset last year, is a delayed-response timer which can turn the respirator off automatically at a pre-determined time. The timer would operate for 24 hours at a time and set off a red light or alarm after 12 hours as a reminder to reset it. The patient or his representative could at any time request an extension, but if the dying person were to insist, the timer would turn off the respirator at the end of the cycle.
This unique system was created by the 59-member Steinberg Committee, which had studied the issue for six years. The legislation was described by then-health minister Dan Naveh as "on the human level, one of the most complicated and most important ever legislated by the Knesset. It is a great moral achievement for the dying and their families."
The ethicist in charge of implementing the law, Dr Mordechai Halperin, says that only a few terminally-ill patients will ask for the timer, but that it had to be an option. He says that the new system will protect doctors who leave themselves open to lawsuits by relatives by following the final instructions of a patient. ~ Jerusalem Post, Nov 12
BRITISH RESEARCHERS NEED HYBRID EMBRYOS
British scientists have applied to create human-animal hybrids in an effort to clarify a gap in existing legislation. Two teams of researchers say that they want to use rabbit, cow and goat eggs to create hybrid embryos, which would be destroyed before reaching 14 days. This appears to be technically possible, as Chinese scientists have already harvested stem cells from such creations.
Under existing legislation, it is illegal to mix human and animal eggs and sperm. (There is already one major exception in IVF clinics, when the quality of human sperm is tested by using it to fertilise hamster eggs.) But it is unclear whether hybrids fall under the remit of the Human Fertilisation and Embryology Authority as these embryos will originate from cloning, not from fertilisation.
The scientists argue that they need animal eggs to practice cloning techniques. Dr Stephen Minger, of King's College, London, told the Telegraph: " "We are concerned that the current state of the technology means that hundreds of eggs from young women will be required to generate a single human embryonic stem cell line. Therefore we consider it more appropriate to use non-human eggs from livestock as a surrogate to generate these disease-specific cell lines until the efficiency of this procedure is improved."
Many people find the prospect of mixing animal eggs and human chromosomes repugnant. Josephine Quintavalle, the director of Comment on Reproductive Ethics, said: "This is abhorrent. It sounds like the craziest kind of science imaginable." However, most observers expect that the HFEA will approve the procedure. ~ London Telegraph, Nov 8
NAZIS' LOW-TECH GENETIC ENGINEERING REMEMBERED
For the first time, children raised in a Nazi program to breed blond, blue-eyed Aryans have met together as adults. Children from the Nazis' "Lebensborn", or "Font of Life", project gathered in the German town of Wernigerode to reflect on their origins.
Although the project has been well documented, many of the children never knew that they were part of it. Between 6,000 and 8,000 illegitimate children were placed in the home of Party members to create a breed of people that fitted the Nazis' physical ideal and could manage a future empire. The children were frequently selected for qualities the Nazis regarded as typically Aryan.
"This is the opposite example of the Holocaust," says Gisela Heidenreich, from Bavaria, whose mother was unmarried and whose father was a senior SS officer. "The idea was to further the Aryan race by whatever means were available." The first of these children to write a first-person account of Lebensborn, Ms Heidenreich says that this sinister program has parallels in contemporary interest in genetic engineering. Its evil must not be allowed to gather dust in history books, she says. "If we start engineering blond-haired, blue-eyed babies, can we blame just Hitler?"
Lebensborn was started in 1936 by Heinrich Himmler to counter Germany's declining birth rate and to assist families of the Nazi elite. There were 11 homes in Germany, several others scattered throughout Europe and possibly as many as 15 in Norway. ~ New York Times, Nov 7; BBC, Nov 4
NY DOC READY FOR WOMB TRANSPLANT
A New York hospital has given the green light for a womb transplant -- even though the only human transplant a few years ago failed and the only successful transplant on a non-human primate was monitored for a mere 20 hours. Dr Giuseppe Del Priore, of New York Downtown Hospital, plans to do another monkey transplant, but he says "if a person walked in tomorrow and requested a uterine transplant, I am cautiously optimistic that we could be successful". He feels that enough experimental work has been done to show that a womb transplant is safe for women. In any case, some surgeons bypass animal experiments to work on humans. A face transplant, first done in France last year, was not performed on a primate first.
Other experts disagree. In September, Richard Smith, of London's Hammersmith Hospital, said that he was two years away from succeeding. And Mats Brännström, of Sweden, says: " we have to do a lot more animal studies before we go on to humans". It could subject women to unnecessary risk, he says. ~ New Scientist, Nov 11
GOTHAM CITY'S FLUID IDENTITIES
Maintaining its reputation for cutting-edge social reform, New York City is soon to allow people to alter the sex on their birth certificate without sex-change surgery. Applicants will have to change their names and show that they have lived in a new gender for at least two years, but they will not be required to undergo a medical check.
The New York Times says that, "It is an outgrowth of the transgender community's push to recognise that some people may not have money to get a sex-change operation, while others may not feel the need to undergo the procedure and are simply defining themselves as members of the opposite sex. While it may be a radical notion elsewhere, New York City has often tolerated such blurring of the lines of gender identity."
The Big Apple has already moved to accommodate transsexuals. Beds in city shelters can be allocated according to appearance and people are allowed to self-define their gender when choosing which subway toilet to use.
A lawyer for the New York Transgender Rights Organization, Joann Prinzivalli, praised the move. Gender identity is based "on an arbitrary distinction that says there are two and only two sexes," he/she said. "In reality the diversity of nature is such that there are more than just two, and people who seem to belong to one of the designated sexes may really belong to the other." ~ New York Times, Nov 7
ONE-CHILD POLICY SHOWS ITS AGE IN CHINA
Confusing signals are emerging from China about its draconian one- child policy. The hard-line position was supported by Zhang Wei- qing, minister in charge of the State Population and Family Planning Commission last week. He said that if the one-child policy had not been in place, China would have had an extra 400 million people. He reiterated the government's determination to keep the population below 1.37 billion by 2010, up from 1.3 billion in 2005.
On the other hand, in Guangzhou, parents who are the only children of their families are being encouraged to have a second child in a drive to rejuvenate the city's ageing population. Local officials insist that this is consistent with national guidelines. "The policy aims to help reduce the pressure on younger members of society caused by ever-increasing ageing populations," said Duan Jian-hua, deputy director of the Guangzhou Population and Family Planning Committee. But few couples are willing to have a second child, due to the increased financial burden. "With both parents coming from one-child families, these couples will bear full responsibility for looking after their parents and children. As a result, many prefer even having no children to having two," he comments.
Demographers have forecast that by the year 2050, one quarter of China's population will be over 65 -- about 400 million people, or nearly as many as the current population of the European Union. ~ China Daily, Nov 9; China Daily, Nov 10; AFP, Nov 10
IN BRIEF: Hwang, Australia, adoption
HWANG: Disgraced South Korean stem cell researcher Hwang Woo-suk is suing Seoul National University to get his job back. He claims that he was unfairly dismissed based on an "inaccurate and false" investigation of his faked research. He says that the university's decision shattered both his career and the hopes of many people who looked to him for medical advances. ~ Chosun Ilbo, Nov 7
AUSTRALIA: Prime Minister John Howard is struggling to make up his mind about therapeutic cloning in the lead-up to a conscience vote in the House of Representatives later this month. The Senate recently approved it by a narrow margin. He said that he was "rather conflicted" by the challenge of deciding whether the possibility of cures outweighed "interfering in fundamental concepts of the beginning of life". ~ AAP, Nov 8
ADOPTION: Agencies in Britain are urging couples in their 40s or even 50s to adopt children. They have found that most people of this age mistakenly believe that they are ineligible. "People are starting their families later and later now, and often don't start trying for children until they are approaching 40," says Sue Cotton, of the children's charity NCH. "If they have trouble conceiving, they may try IVF, which adds on another few years, so often they are in their forties." ~ London Times, Nov 9
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