BioEdge 238 -- Tuesday, 27 February 2007

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BioEdge 238: Women in UK will be paid to donate eggs for research

THIS WEEK


bullet 
Women in UK can donate eggs for research
      Fertility regulator changes policy
bullet 
Egg market booming in US
      Fees used for paying off credit cards
bullet 
Shadow over adult stem cell paper
      Verfaillie accepts university's investigation
bullet 
Is new Dutch government shunning euthanasia?
      Opposition politician criticises palliative care
bullet 
IVF babies more likely to have birth defects
      Canadian data confirms other studies
bullet 
Possible treatment for Down syndrome
      Drug could make it easier to learn
bullet 
New Jersey court considers new argument in abortion debate
      Abortion providers at risk of explaining what happens
bullet 
A decade of Dolly
      Has ethical debate advanced?
bullet 
IN BRIEF: prematurity; liposuction; book banned; South Korea

WOMEN IN UK CAN DONATE EGGS FOR RESEARCH

Never a dull moment in the UK for bioethicists! In the first of two significant developments, the country's fertility regulator has decided to allow women to donate eggs for research in return for compensation. Previously women had only been allowed to donate eggs for IVF procedures.

Angela McNab, chief executive of the Human Fertilisation and Embryology Authority, explained: "women will be allowed to donate their eggs to research, both as an altruistic donor or in conjunction with their own IVF treatment. Given that the medical risks for donating for research are no higher than for treatment, we have concluded that it is not for us to remove a woman's choice of how her donated eggs should be used."

The HFEA stressed that the compensation was tiny, when compared to the effort required to donate. "We need to remind people we are not talking about earnings, we are talking about compensation... comparable to jury service," said a member of the HFEA. It insists that the £250 should not be construed as payment.

Although there has been a lot of publicity lately about the risks of using fertility drugs, the HFEA dismissed these as alarmist. "The risks are incredibly low," said Professor Emily Jackson, another member of the HFEA.

In another development, the director of the lobby group Human Genetics Alert has warned that the government is drafting legislation which could lead to genetic engineering. David King pointed out that the overhaul of the UK's fertility legislation will probably include provisions for genetic alteration of human embryos. A white paper on the topic has already said that that germline modification should be banned -- but only "until such time as safety and efficacy are ensured".

The editor of the Bulletin of Medical Ethics, Dr Richard Nicholson, commented that "Every country that has legislated on this subject has banned it. Thus the British Government's decision breaks ranks with the international community, and may lead to the perception that Britain is a haven for irresponsible and profit-driven scientists." ~ London Telegraph, Feb 25; Guardian, Feb 21; BBC, Feb 21   

EGG MARKET BOOMING IN US

While compensation for egg donation is hotly debated in the UK, it has become common in the US. According to guidelines from the American Society of Reproductive Medicine, women should receive between US$5,000 and $10,000. In 1996 women in federally monitored programs donated eggs about 3,800 times. By 2004, the figure had risen to 10,000 times. The demand seems to be fuelled by the rising number of older women on IVF programs. It will grow as more states fund stem cell research programs, which will require eggs. Anecdotal evidence suggests that fees for premium donors can be well above $10,000.

Everyone does it for the money," says Jennifer Dziura, a donor, in an interview with AP. "No one would do that for free; maybe for your sister, but not for a stranger." This is disputed by the president of the Society for Assisted Reproductive Technology, Dr David Grainger. He says that non-altruistic donors would not pass a clinic's screening test. However, one woman who later regretted donation told AP that she had convinced herself that she was doing it for altruistic motives. But, she said, "if I'm honest, I did it for financial reasons; I wanted to travel.".

A small survey from a fertility clinic in Illinois indicates that donors used their fees for everything from down payments on property to school expenses. Half of them used some of the money to pay off credit card debts and other loans. ~ AP, Feb 19   

SHADOW OVER ADULT STEM CELL PAPER

An important paper which claimed that a type of adult stem cell was as versatile as embryonic stem cells now appears to be flawed. In 2002, Catherine Verfaillie, of the University of Minnesota, discovered that stem cells taken from the bone marrow of mice could grow into an array of tissues, including brain, heart, lung and liver. Without any encouragement from her, the paper was used by opponents of embryonic stem cell research as proof that adult stem cells were viable alternatives to those taken from embryos.

Dr Verfaillie's results proved hard to repeat. Some other scientists were unable even to isolate the cells, called multipotent adult progenitor cells (MAPCs). When the magazine New Scientist examined the original paper more closely, it found that some data from her original paper in Nature and another of her papers published at the same time were identical, even though they were supposed to refer to different cells. This led to an investigation by the University of Minnesota, which recently concluded that identification of her cells was "significantly flawed" and that interpretations of her data were potentially incorrect". Dr Verfaillie, who is now at the Catholic University in Leuven, Belgium, has accepted the results of the investigation. It appears that the duplication was an oversight, and that there is no question of falsification.

Nonetheless, to make a complicated story even more complicated, Verfaillie's work is far from being totally discredited. In collaboration with a leading sceptic of her work, Irving Weissman, of Stanford, she has succeeded in making MAPCs rebuild the blood system in mice. "What our paper will help do is get everybody to look at [her work] again," says Weissman. ~ Science, Feb 9; New Scientist, Feb 15; Seattle Times, Feb 24   

IS NEW DUTCH GOVERNMENT SHUNNING EUTHANASIA?

A Dutch politician has complained that his country's new government plans to create viable alternatives to abortion and euthanasia. The leader of the Liberal party, Mark Rutte, complains that the coalition wants to urge pregnant women to consider adoption as an alternative for abortion. He says that adoption can be psychologically harmful for the child and its mother. He also fears that the government will try to make euthanasia superfluous by supporting palliative care as full-fledged alternative. Rutte claims euthanasia should remain an "independent alternative" in situations of unbearable and untreatable suffering. ~ Expatica, Feb 26   

IVF BABIES MORE LIKELY TO HAVE BIRTH DEFECTS

Canadian research indicates that babies conceived through IVF are more likely to have birth defects, confirming studies in Australia and the US. In the latest study, researchers analysed 61,208 deliveries in Ontario and found that the 1,394 IVF babies were about 60% more likely to have birth defects. The most common of these were gastrointestinal defects, but the babies also had more bone, muscle and heart-related defects. Scientists are unsure what could be the cause. Some suggest the fertility drugs taken by the mother; some point to unknown features of a couple's infertility; some ask whether three days in a Petri dish might interfere with an embryo's development. The research was presented at a meeting of the Society for Maternal-Fetal Medicine in San Francisco. ~ New Scientist, Feb 24   

POSSIBLE TREATMENT FOR DOWN SYNDROME

A possible new use has been discovered for an old epilepsy drug -- giving people with Down Syndrome new capacity for learning. An article in Nature Neuroscience suggests that the drug, pentylenetetrazole, or PTZ, helped specially-bred mice with Down Syndrome to learn more like normal mice. Apparently PTZ, which is no longer approved for use with humans, stimulates brain cells and enhances learning. "This treatment has remarkable potential," said Craig Garner, a professor of psychiatry and a director of the Down Syndrome Research Center at California's Stanford University. "So many other drugs have been tried that had no effect at all. "Our findings clearly open a new avenue for considering how cognitive dysfunction in individuals with Down syndrome might be treated." ~ Reuters, Feb 25   

NEW JERSEY COURT CONSIDERS NEW ARGUMENT
    IN ABORTION DEBATE

The New Jersey Supreme Court is considering a case which could shake up America's tortuous abortion debate. An article in Slate sketches the facts. Rose Acuna, a 29-year-old mother of two, went to her doctor, Sheldon Turkish, complaining of abdominal pain. She was between five and seven weeks pregnant. She says she asked Dr Turkish if a "baby were already there" and he responded "Don't be stupid, it is nothing but blood." Ms Acuna had the abortion, but soon repented. In 2004, she sued Dr Turkish for medical malpractice, arguing that abortion providers have a duty to tell their clients that the foetus or embryo is "a complete, separate, unique and irreplaceable human being" and than an abortion would kill that human being.

Acuna and her lawyer, Harold Cassidy, lost the first round, before a trial judge, but won the second round before an appeals court, which ruled that the case could go before a jury. Abortion clinics do not want this, as it would effectively force them to tell patients that the foetus is an existing human being to head off the threat of later lawsuits. So the case has now moved on to the Supreme Court. If it decides in Acuna's favour, clinics in New Jersey, and probably elsewhere, will be forced to discuss abortion in completely different terms. The procedure will not be banned, but doctors will have to acknowledge that they are killing a human being. Stay tuned. ~ Slate, Feb 20   

A DECADE OF DOLLY

February 22 marked the tenth anniversary of the cloning of Dolly. Back in 1997, Ian Wilmut and his colleagues at Roslin Institute near Edinburgh announced that they had produced a lamb genetically identical to an adult ewe. This development ignited one of the biggest debates on the ethics of scientific research in decades. It also opened up exciting new possibilities for stem cell research and therapeutic cloning.

Curiously, the intensity of public interest caught scientists off guard, even the journal Nature which published Wilmut's research. While the popular media instantly focused on the science fiction scenario of battalions of goosestepping Hitlers, scientists saw Dolly merely as an incremental step forward from a paper published the year before. The cloning debate has since moved on to the pros and cons of therapeutic cloning, ie, cloning and destroying embryos for their stem cells.

Nonetheless, reproductive cloning remains the most potent of the "yuk!" arguments against cloning embryos and no reputable scientist will be caught dead endorsing it. Normally the reason given is that reproductive cloning is bound to be unsafe for the child. Cloned animals, including Dolly, tend to be sickly and deformed.

However, it has also become clear, after ten years, that most scientists working in the field will back human reproductive cloning if it ever becomes safe. Many prominent bioethicists and lawyers have already constructed arguments to justify it. A manifesto released by the world's scientific academies has failed to rule it out.

Nature acknowledged this in an editorial last week: "But as the science of epigenetics and of development inevitably progresses, those for whom cloning is the only means to bypass sterility or genetic disease, say, will increasingly demand its use. Unless there is some unknown fundamental biological obstacle, and given wholly positive ethical motivations, human reproductive cloning is an eventual certainty." ~ Nature, Feb 22   

IN BRIEF: prematurity; liposuction; book banned; South Korea

Record for prematurity: A Florida IVF baby born at 21 weeks and 6 days has been released from hospital. She is the first baby known to have survived after a gestation period of less than 23 weeks. She has battled with respiratory and digestive problems, but doctors now say that her prognosis is "excellent". ~ AP, Feb 19

Liposuction as source of stem cells: A Norwegian doctor has discovered certain chemical markers in fat cells which show whether they can be transformed into other cell types. "Fat tissue is an under-appreciated source of stem cells," says Philippe Collas. "It's wonderful. We have litres and litres of material from cosmetic surgery clinics and end up with bucketfuls of stem cells to work with". ~ European Science Foundation, Feb 22

Book banned: A book by Australian euthanasia activist Dr Philip Nitschke has been banned by the Australian government. The Peaceful Pill gives instructions for a lethal homebrewed barbiturate. The decision by the Classifications Review Board means that the book cannot be sold, displayed or imported into Australia. ~ Australian Government press release, Feb 24

Korea to rejoin stem cell race: The South Korean government has budgeted US$33 million for stem cell research in 2007, up 20% from last year. It is believed that the National Bioethics Committee will also recommend resumption of experiments with cloned human embryos. These stopped abruptly after the Hwang scandal. Fourteen of the 20- member committee are backing the research -- seven scientists and seven government officials. Only the six bioethicists on the committee oppose it. ~ Korea Times, Feb 22   

 

  

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Australasian Bioethics Information
ISSN 1446-2117
Website:www.australasianbioethics.org
BioEdge editor: Michael Cook
New Zealand Contributing Editor: Carolyn Moynihan


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