BioEdge 243 -- Wednesday, 11 April 2007

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BioEdge 244: Chimps could get human rights in Austria

THIS WEEK


bullet 
Chimps could get human rights in Austria
      No clear boundaries between apes and humans
bullet 
Stem cells back in US Senate
      Debate begins again
bullet 
Will IVF save falling birth rates?
      Marginal increase in Denmark
bullet 
China revises organ donation law
      But human rights activists are sceptical
bullet 
British pressure to allow embryo hybrids
      Needed for research, say scientists
bullet 
Is God all in the brain, ask neuroscientists
      The expanding field of neurotheology
bullet 
Heart valve cells grown from adult stem cells
      In ten years we could grow a whole heart, says surgeon
bullet 
Does Korea have another stem cell debacle on its hands?
      Controversy over plagiarised paper
bullet 
IN BRIEF: mercy killing; bad news; confidentiality

CHIMPS COULD GET HUMAN RIGHTS IN AUSTRIA

An Austrian court is studying whether a 26-year-old chimpanzee should be given human rights and treated as an asylum-seeker from Sierra Leone. Hiasl, a lively and affectionate animal who recognises himself in a mirror and plays hide-and-seek, would be saved from a vivisection laboratory if the court appoints a human guardian for him. His supporters contend that he is equivalent to a human. They argue that a chimp's DNA is about 98% similar to a ours. They can use tools and have an emotional life.

Animal experts are queuing up to support the case. Professor Volker Sommer, a chimp expert at University College London, says that "It's untenable to talk of dividing humans and humanoid apes because there are no clear-cut criteria, neither biological, nor mental, nor social."

However, Steve Jones, a professor of genetics at the University of London, counters that it is absurd to speak of human rights for the great apes. "Where do you stop?" he asked the BBC. "Being human is unique and nothing to do with biology. Say that apes share 98% of human DNA and therefore should have 98% of human rights. Well, mice share 90% of human DNA. Should they get 90% of human rights? And plants have more DNA than humans..." ~ BBC, Mar 29; Observer, Apr 1   

STEM CELLS BACK IN US SENATE

Once again, the US Senate will be debating embryonic stem cell research. It will consider two bills this week: one which is nearly the same as a bill vetoed by President Bush last year which will expand and encourage this research. The other is a compromise measure which will foster research on "dead" human embryos or on cells extracted from living embryos without destroying them. It also will support the creation of a stem cell bank for cells extracted from amniotic fluid and placentas.

The looming debate was the occasion for some thoughtful commentary from both sides of the debate. Harvard professor Michael Sandel, a supporter of destructive embryo research, points out in the Boston Globe that President Bush's position is inconsistent. If he really does believe that embryos are human persons, surely he ought to seek to ban it completely, not merely deny it federal funding.

And in National Review an opponent, Yuval Levin, of the Ethics and Public Policy Center, zeroes in on an inconsistency in the first bill, which was passed last year by the House of Representatives. However, its supporters have now added provisions for funding alternatives such as reprogramming adult cells and deriving stem cells from amniotic fluid. These methods have shown great promise in recent months, probably more than embryonic stem cells. So what is the point of federal funding research for destructive methods "just at the moment when ethical alternatives may be emerging", he asks. ~ National Review, Apr 9; Boston Globe, Apr 8; Reuters, Apr 9   

WILL IVF SAVE FALLING BIRTH RATES?

With birth rates in Europe sinking to unprecedented lows, one country seems to have bucked the trend. At the moment Denmark has a birth rate of 1.9, almost replacement level. And the difference seems to be the incredible popularity of IVF there. Nearly 1 Danish baby in 20 is an test-tube baby. IVF is widely accepted, receives big government subsidies and waiting times for treatment are short.

Austrian demographers studied Danish birth rates and concluded that with IVF included in their analysis, the birth rate was steady. Without it, it declined to below 1.8 children per woman. Since an important reason for declining birth rates is delayed child bearing, this suggests that making IVF readily available for women over 35 helps to keep the birth rate up.

Their findings support a discussion paper from the think tank RAND Europe which argued last year that IVF might help raise European birth rates. However this was just one of a range of policy measures which governments ought to consider and one which would have to be used with great discretion, the Rand analysts warned. If IVF became even more available, an uptick in the birth rate could be offset by an increase in women delaying child-bearing until it was too late even for an IVF birth. ~ New Scientist, Apr 6; Rand Europe, 16 June 2006   

CHINA REVISES ORGAN DONATION LAW

In response to international pressure, China has revised its regulations for organ transplants. The State Council, or Cabinet, has banned the sale of human organs for profit, donations by people under 18, and the use of organs without informed consent.

However, human rights groups were sceptical of genuine improvements in China's opaque system for obtaining organs. The official news agency Xinhua maintains that most come from deceased donors who have voluntarily donated. While this may be true, in 90% of these cases, the cause of decease is a judicial execution. If so, voluntary consent is virtually meaningless, claims Nicholas Bequelin, of Human Rights Watch.

Chinese legislators have been pushing for new laws to regulate and promote voluntary donation to prevent abuses. However, the rate of voluntary donation is very low, due in part to a cultural bias against removing organs before burial. ~ Washington Post, Apr 7   

BRITISH PRESSURE TO ALLOW EMBRYO HYBRIDS

Pressure is growing on the British government to permit the creation of human-animal hybrid embryos for stem cell research. After a recent public consultation, it appears that the government is preparing to ban it, but there have been noisy protests from scientists and MPs. The Association of Medical Charities has sent a letter to Prime Minister Tony Blair signed by 223 medical foundations and patient groups.

Whatever the public might feel, suggests the letter, the views of scientists should prevail: "They highlight the need for this work because of the shortage of human eggs for medical research and because they see it as a vital avenue of inquiry which could greatly increase our understanding of serious medical conditions and ultimately lead to new treatments."

Within Parliament, members of a science and technology select committee are giving hybrid embryos vigorous support. "Ministers have never provided a rational basis for their ban and their only supporters are pro-life groups and anti-science campaigners who oppose all embryo research," says MP Evan Harris.

However, Josephine Quintavalle, director of Comment on Reproductive Ethics, said: "Despite the enthusiasm of this small committee, worldwide there is more opposition than support for the creation of such entities, and within the United Kingdom as well. The public should now demand an extensive and objective consultation at the highest democratic level, and by this we mean Parliament itself." ~ BBC, Apr 5; AMC website   

IS GOD ALL IN THE BRAIN, ASK NEUROSCIENTISTS

Last week BioEdge's lead story featured research which points to the brain as the source of ethics. An even more daring theory is that the brain is the source of God. According to Andrew Newberg, a neuroscientist, or rather, a neurotheologian, human beings are hard- wired to believe in God. Like a number of other researchers, he believes religion and spirituality can be explained in terms of brain processes. The frontal lobe helps to focus attention in prayer; the parietal lobe is involved in the feeling of becoming part of something greater than oneself; the limbic system is responsible for feelings of joy and awe.

A number of recent books support variations of this claim. There is In Gods We Trust: The Evolutionary Landscape of Religion, by anthropologist Scott Atran. Last year Newberg published Why We Believe What We Believe: Uncovering Our Biological Need for Meaning, Spirituality, and Truth. Matthew Alper also released last year a revised edition of his 1996 book The 'God' Part of the Brain: A Scientific Interpretation of Human Spirituality and God.

Of course, such ideas are hardly novel. Marx said that religion was invented to oppress the working class; Freud believed that it was an illusion which sprang from unresolved sexual conflicts. William James claimed that religious experience could be induced with drugs. But the increasing power and prominence of neuroscience suggest that in the future theological debates will centre on the brain. ~ CNN.com, Apr 4   

HEART VALVE CELLS GROWN FROM ADULT STEM CELLS

Bone marrow stem cells have been used to create heart valve cells, raising hopes that an entire heart could be grown from stem cells within 10 years. British heart surgeon Sir Magdi Yacoub, of Imperial College London, extracted stem cells from bone marrow, cultivated them into heart valve cells, and the placed them on biodegradable "scaffolds". They grew into 3cm wide disks of heart valve tissue. Later in the year, the valves will be tested on animals.

Growing heart valves is a big step forward in scientists' efforts to grow whole organs from stem cells. They have already grown tendons, cartilages and bladders from adult stem cells.

Sir Magdi said the possibility of growing an entire heart was "an ambitious project but not impossible". "If you wanted me to guess, I'd say ten years," he said. "But experience has shown that progress that is happening nowadays make it possible to achieve milestones in a shorter time. I wouldn't be surprised if it was sometime sooner than we think." Daily Mail, Apr 5   

DOES KOREA HAVE ANOTHER STEM CELL DEBACLE ON ITS HANDS?

The South Korean government plans to invest nearly half a billion dollars into gaining pole position in global embryonic stem cell research. After the worst case of fake research in living memory, more scandal is not what it needs. But that is what is happening. As reported in last week's BioEdge, Kwang Yul Cha, a Korean who is a front-runner to succeed Hwang Woo-suk as his nation's premier stem cell researcher, is embroiled in a plagiarism scandal.

The increasingly messy dispute is described in the current issue of the British Medical Journal. Jeong Hwan Kim, a Korean doctor now working in Singapore, wrote a PhD on premature ovarian failure. His conclusions were published as a Korean-language paper in the Korean Journal of Obstetrics and Gynaecology in January 2004. Much to his surprise, he discovered that substantially the same paper was published in English in the leading journal Fertility and Sterility in December 2005 without his knowledge. Six authors were listed -- and he was not one of them. The leading author was his former boss, Dr Cha, and another was the head of genetics at CHA General Hospital, Sook Hwan Lee.

Without going into all the claims and counter claims, the current situation is as follows. Dr Lee is now facing criminal copyright infringement charges in Korea. Dr Cha's lawyers have accused Fertility and Sterility of defamation. The Korea journal has demanded that the American journal issue a retraction on the ground of duplicate publication. The CHA group has described Dr Kim as a bit player in the research whose email address was lost after he moved to Singapore.

The meat in the sandwich is Kwang Soo Kim, a Harvard professor who had joined the CHA research group only a short time before the scandal broke. He now has the unenviable task of both defending his colleagues and conducting his own campaign for Western standards of publication in Korea. If the issue cannot be smoothed over, a US$2.6 million research grant which CHA received from the California Institute for Regenerative Medicine is at risk.

Will a clear moral emerge from this tangled tale of cultural clashes, deceit, national pride and laboratory power plays? None, perhaps, except that the full spectrum of human failings is hard-wired into embryonic stem cell research and that professional and government regulators need to take this into account. ~ BMJ, Apr 7   

IN BRIEF: mercy killing; bad news; confidentiality

Australian mercy killing: Parents who killed their 28-year-old severely disabled son have been placed on a five-year good behaviour bond after pleading guilty. Their child, Matthew, was born blind and had limited hearing. Margaret and Raymond Sutton acted after they learned that he needed an operation which would also take away his ability to hear, taste and speak. A pro-life spokesman denounced the lack of support for the couple's emotional, psychological and physical needs. Euthanasia campaigner Philip Nitschke said that the case should not have come to trial at all. ~ Australian, Apr 5

More bad news for boys: Adult stem cells from females are more successful at regeneration than those from males, scientists at the Pittsburgh School of Medicine have found. "Regardless of the sex of the host, the implantation of female stem cells led to significantly better skeletal muscle regeneration," they wrote in the Journal of Cell Biology. ~ MSNBC.com, Apr 9

GPs accused of breaching confidentiality: Britain's health minister, Patrician Hewitt, has declared that some Muslim family doctors may be relaying details of the sexual health of female Muslim patients to their families. This was angrily denied by Muslim GPs, who said that her claims were based only on hearsay. ~ BMJ, Apr 7   

 

  

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Australasian Bioethics Information
ISSN 1446-2117
Website:www.australasianbioethics.org
BioEdge editor: Michael Cook
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