BioEdge 251 -- Wednesday, 30 May 2007

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BioEdge 251: The IVF industry's best-kept secret

THIS WEEK


bullet 
The IVF industry's best-kept secret: selective reduction
      No statistics kept by government or industry
bullet 
Presenting Holland's organ donor circus
      Reality TV takes a new turn
bullet 
Altruism is all in the brain
      Goodness gives good vibes in brain
bullet 
Stem cell progress
      Promising developments with urinary incontinence
bullet 
Top drug official to be executed in China
      Government fed up with scandals
bullet 
Abortion rights in search of abortion doctors
      Abortion providers may be a dying breed
bullet 
Dispute over huge experiment without informed consent
      Bioethicists at loggerheads
bullet 
Kevorkian to be paroled
      Vows not to participate inassisted suicides
bullet 
Botched execution
      Two hours needed to kill Ohio convict

THE IVF INDUSTRY'S BEST-KEPT SECRET: SELECTIVE REDUCTION

One of the best-kept secrets of IVF is selective reduction -- killing one or more foetuses in the womb of a woman who is carrying twins, triplets or quadruplets. In a new book, "Everything Conceivable", Washington Post writer Liza Mundy describes how it works. She conducted an in-depth interview with Manhattan obstetrician Mark Evans, one of the few American doctors who is willing not only to do reductions, but to discuss them and rationalise them.

Little is known about how widespread the practice is. Because of the growing number of pregnancies achieved with assisted reproduction techniques, including IVF and artificial insemination, there has been an explosion of high-risk multiple pregnancies. But no one keeps statistics on how many of these are "reduced". The US Centers for Disease Control and Prevention publishes an annual report on fertility clinic outcomes, but not on this procedure. The fertility industry does not keep statistics either. "This is a very sensitive topic," says David Grainger, president of the Society for Assisted Reproductive Technology.

Ms Mundy sat in on several interviews which Dr Evans had with his patients: a couple with IVF triplets (reduced from three to two), a lesbian couple with quads (four to two), and a young and immature Puerto Rican woman with triplets who had flown in from San Juan with her mother, her grandmother and another older woman (three to two).

Dr Evans has constructed his own bioethics on the fly, as the demand for various services fluctuated over the past 20 years. When he began work, 40 to 45% of his patients had quads. Now it is only 20%. At first he regarded it as unethical to reduce a normal twin pregnancy. Nowadays, he is willing to reduce from two to one. He argues that if it is OK to reduce from one to none (if one accepts abortion as ethical), then it must be OK to reduce from two to one.

The effects of reduction upon the mother and her relationship with the surviving children are not well understood either. The immediate feeling is relief, but later on women may feel depressed. An authority in multifoetal pregnancies, Isaac Blickstein says, "psychoanalytic interviews with women who underwent [selective reduction] describe severe bereavement reactions including ambivalence, guilt, and a sense of narcissistic injury, all of which increased the complexity of their attachment to the remaining babies." Washington Post, May 20   

PRESENTING HOLLAND'S ORGAN DONOR CIRCUS

Do you think that TV can't get any worse? Think again. Prepare for the Big Donor Show, a one-off 80-minute Dutch reality TV program in which a dying woman decides which of three sick patients will get her kidneys. It is "degrading and heartless" in the opinion of some Dutch parliamentarians, but the production company, Endemol, insists that it is in the public interest. "It's to boost public awareness about a shortage of organs for transplant," explained a spokesman.

It is also in memory of the memory of the founder of the network on which the show will be broadcast, Bart de Graaff, who died five years ago at the age of 35 from kidney failure.

A 37-year-old woman named Lisa with an inoperable brain tumour will interview candidates. Viewers will be cast their votes for the one they like best by sending an SMS text message. "We know that this program is super-controversial and some people will think it's tasteless, but we think the reality is even more shocking and tasteless. Waiting for an organ is just like playing the lottery," explained the chairman of the BNN network.

Despite the hoopla surrounding the donation, it may not happen anyway. According to Dutch law, only living donors can direct donations. Organs from deceased donors go to the neediest candidate on a national waiting list.

Education minister Ronald Plasterk said that the program was "unfitting and unethical" but it would be censorship to ban it. ~ AP, May 29   

ALTRUISM IS ALL IN THE BRAIN

The Paradox of Altruism Evidence that morality is all in the brain keeps rolling in. The Washington Post recently highlighted research from the National Institutes of Health that appeared to show that altruism feels good and is hard-wired into the brain. Jordan Grafman and his colleagues found that when volunteers placed the interests of others above their own, lights went on in a primitive part of the brain which usually responds to food or sex.

The neuroscientists who are working on experiments of this kind believe that morality and immorality can be reduced, broadly speaking, to brain chemistry rather than free will. "Eventually, you are bound to get into areas that for thousands of years we have preferred to keep mystical," says Dr Grafman. "Some of the questions that are important are not just of intellectual interest, but challenging and frightening to the ways we ground our lives. We need to step very carefully."

Harvard research Marc Hauser goes even further. He believes that morality is like language. People may be able to reach moral conclusions in the same way that they construct sentences, without having been trained in linguistics, because its foundations are basically neurological. ~ Washington Post, May 28   

STEM CELL PROGRESS

Adult stem cells have been used to deal with urinary incontinence, an increasingly common problem amongst older women. In the past, the problem had been treated with surgery, but this is invasive and patients are often reluctant. In a small study of 8 women presented at the American Urological Association, researchers from the University of Pittsburgh Medical Center injected women with their own stem cells. Five reported improvement and one is completely dry. In a similar study at the Medical University of Innsbruck in Austria, found that 80% of patients' incontinence was cured and that the results do not appear to fade over time.

A woman's fat cells may provide another option , according to Tom Lue, of the University of California San Francisco. In animal experiments, he found that stem cells harvested from fat became muscle tissue as well as blood vessel and fat tissues. And by using a person's own stem cells, Lue says, "we bypass immunology problems and ethical concerns." Another researcher found promising results with stem cells isolated from urine.

In another development, researchers at the University of Newcastle, in Britain, believe that they are able to engineer stem cells taken from the umbilical cords of newborn babies to get them to produce insulin. Writing in the journal Cell Proliferation, they say that they might be able to provide an alternative to human embryonic stem cells. A leading embryonic stem cell researcher in the US, Rudolph Jaenisch, however, tipped cold water on their claims. "In the past, these claims have been rather unconvincing," he told Reuters. ~ USAToday, May 21   

TOP DRUG OFFICIAL TO BE EXECUTED IN CHINA

The former head of China's Food and Drug Administration has been sentenced to death for taking US$850,000 in bribes and allowing tainted foodstuffs and medicines to be sold. Zheng Xiaoyu was commissioner of the FDA from its founding in 1998 to 2005. After several scandals abroad featuring tainted food and fake drugs, the Chinese government is cracking down hard.

Recently contaminated pet food was shipped to the US, but this may be just the tip of the iceberg. In Panama, more than 100 people died last year after drinking cough syrup laced with a toxic chemical sometimes used to make antifreeze. In China itself, thousands of people fall ill or die because of widespread counterfeiting of drugs and substandard food. The government is now reviewing more than 170,000 production licenses issued by the food and drug agency over the past 10 years. "The death penalty wouldn't be excessive punishment for Zheng," Wang Yigao, a professor at the Hunan Academy of Sciences told the New York Times. ~ New York Times, May 29   

ABORTION RIGHTS IN SEARCH OF ABORTION DOCTORS

A new generation of abortion specialists is springing up in the US, according to the Los Angeles Times, energised by the plight of women who have to travel miles and miles to find a doctor willing to do terminations. "It doesn't matter what you believe if you don't back it up with action," says Michelle Cleeves, a medical student at the University of Colorado. "The right to abortion doesn't mean anything if women don't have access."

The question is whether there will be enough enthusiasts to offset a sharp decline in numbers. Although abortion is said to be one f the most common surgical procedures in the US, the number of providers has fallen for decades. It dropped 37% between 1982 and 2000, with the number of abortions reportedly dropping by 17%.

The Guttmacher Institute, which is associated with Planned Parenthood, says that there were only 1,800 abortion providers in the US in 2000 -- compared with 6,200 plastic surgeons, 9,700 dermatologists and 10,600 gastroenterologists. One in four women must travel at least 50 miles to end their pregnancy. Nearly one- third of metropolitan areas and 97% of rural counties have no abortion providers.

Older doctors, however, are not upbeat about their specialty. Dr Warren Hern, of Boulder, Colorado, described by the Times as "a legend in the abortion rights movement", has some disheartening advice for medical students. "Do something else. Fix broken legs. No reasonable person would do this," he says. Abortion has become so stigmatised that other doctors shun him. Even his patients look at him with disgust. "They've absorbed so much anti-abortion rhetoric, they feel a sense of revulsion that they have to come into my office and seek treatment."

Dr Hern specialises in second and third trimester abortions and even he feels unnerved by what he does sometimes. He once wrote that "the sensations of dismemberment flow through the forceps like an electric current". "We are hard-wired as a species to protect small, young helpless creatures," he says. "The foetus is not a baby, but it's close. Some are very close. It's difficult"

The upshot of this is that medical students who want to do abortions must be highly committed. Most medical schools barely cover the topic and only half of the obstetrics and gynaecology residencies integrate abortion into physician training. Keen students must study on their own. ~ Los Angeles Times, May 22   

DISPUTE OVER HUGE EXPERIMENT WITHOUT INFORMED CONSENT

The US government is undertaking an ambitious US$50 million project over five years to conduct emergency medical treatment without obtaining consent from patients. It will involve more than 20,000 people in 11 sites across the US and Canada.

Although consent is a basic principle of contemporary bioethics, it can be difficult to get it from people involved in accidents, shootings and heart attacks. For instance, in one experiment, medics will test which is the more effective treatment for cardiac arrests by randomly infused some patients with "hypertonic" solutions containing high levels of sodium, with or without the drug dextran. Other studies have suggested that hypertonic solutions could save more lives and minimise brain damage.

To allay fears of the public, researchers will conduct a "community consultation" process at each site. Anyone who objects will be provided with a special bracelet to alert medical workers.

Even bioethicists are divided on the issue. "This just seems like lazy investigators not wanting to try to get informed consent in situations where it is difficult to get it, so they say it is impossible," says George J. Annas, a prominent bioethicist at Boston University. "I don't think we should use people like this." However, Myron L. Weisfelt, of the Johns Hopkins School of Medicine, says that some people will object to any experiment done without consent. "We will never know the best way to treat people unless we do this research," he says. "And the only way we can do this research, since the person is unconscious, is without consent." ~ Washington Post, May 27   

KEVORKIAN TO BE PAROLED

America's icon of assisted suicide, Jack Kevorkian, will be able to celebrate his 79th birthday in relative freedom next week. After eight years in a Michigan jail for helping a man with Lou Gehrig's disease to die, he will be paroled on June 1. His attorney says that Kevorkian is a very sick man who suffers from Hepatitis C and hardening of the arteries in the temples. His client has vowed not to break the law again. Instead he will focus on educating the public about his position on assisted suicide.

Kevorkian has become something of a hero for the voluntary euthanasia movement, especially after being jailed. "You'd be surprised at how many people have written to me and offered to have him stay at their homes when he gets out of prison," says his lawyer. "The man is an icon, but that's neither here nor there." ~ ABC News, May 25   

BOTCHED EXECUTION

The notion that any form of the death penalty must be considered "cruel and unusual punishment" has received a boost from the execution of 37-year-old Christopher Newton in the American state of Ohio. The 265-pound man had been condemned to death for murdering a prison cell mate in 2001. He insisted that he wanted to die and made no attempt to appeal his sentence.

His execution took two hours -- so long that he was given a bathroom break during the process. The execution team stuck him at least 10 times with needles to insert the shunts for a lethal injection. He laughed and chatted with the prison staff throughout the process. ~ AP, May 25   

  

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Australasian Bioethics Information
ISSN 1446-2117
Website:www.australasianbioethics.org
BioEdge editor: Michael Cook
New Zealand Contributing Editor: Carolyn Moynihan


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