BioEdge 251 -- Wednesday, 6 June 2007

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BioEdge 252: Pfizer sued by Nigeria over drug trial

THIS WEEK


bullet 
Pfizer sued by Nigeria over drug trial
      Government claims drug trial killed 11 children
bullet 
We were hoaxed
      Dutch reality TV program a sham
bullet 
IVF expert puts boot into IVF industry
      Lord Winston says industry corrupted by money
bullet 
US Govt to stop breeding chimpanzees for research
      Too expensive to provide lifetime care
bullet 
Pepsi and Coca-Cola to abandon animal testing
      Pressure from animal welfare lobby
bullet 
IVF begins in Uganda
      Profile in local paper
bullet 
Swiss suicide clinic under attack
      Zurich prosecutor says some patients depressed
bullet 
Sperm donors undervalued, says study
      Victims of gender stereotypes
bullet 
Kevorkian leaves jail
      But will observe parole conditions
bullet 
Medical tourism soaring
      New global industry for developing world
bullet 
IN BRIEF: sextuplets; assisted suicide; coma

PFIZER SUED BY NIGERIA OVER DRUG TRIAL

For the first time, a developing country is pursuing a Big Pharma company over a badly conducted drug trial. Nigeria is suing Pfizer for carrying out illegal trials of an anti-meningitis drug that it claims killed 11 children and disabled others in 1996. It is seeking more than US$2.7 billion in damages. Criminal charges, including criminal conspiracy and voluntarily causing grievous harm, have also been filed against Pfizer and eight current or former executives and researchers.

The incident inspired John Le Carré's novel The Constant Gardener and the subsequent film.

The trial of a drug called Trovan, which was never approved for children in the US, was carried out in the state of Kano. The Nigerians claim that parents were not told that the drug was experimental, that consent was not obtained, and that the company removed all medical records and "obliterated any evidence" of the trial. The local population is still so incensed over the incident that parents have refused to vaccinate their children against polio, to the government's dismay.

Pfizer has indignantly rejected the allegations. A spokesman in New York said the drug had been administered in accordance with Nigerian law, that it had been conducted ethically and that it helped to save lives. ~ Guardian, June 6   

WE WERE HOAXED

Along with everyone else, BioEdge has been hoaxed by a Dutch reality TV show. Last week we reported that a woman dying of a brain tumour would appear on TV to select a person who would receive her kidneys when she died. Shock & horror! Disgust & revulsion!

Well, even though this may have pushed the boundaries of media ethics, it was not a bioethical issue. It turns out that the woman was an actress - a secret kept under wraps until the moment when she was about to make her choice. "We are not giving away a kidney here.

That is going too far even for us," said the show's presenter. The producers said that they wanted to highlight an organ donor shortage in the Netherlands. Dutch Culture Minister hailed the show as a "fantastic stunt". ~ BBC, June 2   

IVF EXPERT PUTS BOOT INTO IVF INDUSTRY

Lord Robert Winston The contrarian Lord Robert Winston, one of the pioneers of IVF, has once again attacked his colleagues in the IVF industry, this time for having been corrupted by money and for exploiting women who are desperate to get pregnant. "One of the major problems facing us in healthcare is that IVF has become a massive commercial industry," he said at the Guardian Hay Festival. "It's very easy to exploit people by the fact that they're desperate and you've got the technology which they want, which may not work."

Lord Winston was particularly scathing about his London colleagues: "Amazing sums of money are being made through IVF. It is really rather depressing to consider that some IVF treatments in London are charged at 10 times the fee that is charged in Melbourne, where there is excellent medicine, where IVF is just as successful, where they have comparable salaries. So one has to ask oneself what has happened. What has happened, of course, is that money is corrupting this whole technology."

Nor did he spare the UK's fertility watchdog, the Human Fertility and Embryology Authority: "The regulatory authority has done a consistently bad job. It's not prevented the exploitation of women, it's not put out very good information to couples, it's not limited the number of unscientific treatments people have access to, it doesn't prevent sex selection and all sorts of other things people don't like because there are all sorts of ways around the law." ~ Guardian, May 31   

US GOVT TO STOP BREEDING CHIMPANZEES FOR RESEARCH

The National Institutes of Health in the US has declared that it will no longer breed chimpanzees for medical research. Although since 1995 a temporary moratorium on breeding had been in place anyway, the current decision makes it permanent. Authorities acknowledge that chimps are valuable for medical research, but that caring for them simply costs too much. Since 2000, chimps may not be euthanased after they are no longer useful for scientific studies, but must be pensioned out to a wildlife sanctuary. It can cost US$500,000 to care for a chimp over its 50-year lifespan.

Scientists differed over the impact that the new policy would have upon research. Some feel that private enterprise will breed and support the next generation. Others say that it could affect progress in finding a vaccine for Hepatitis C, since chimpanzees are the only animals which can be infected with the virus. The decision was hailed by animal rights groups. ~ The Scientist, Jun 5   

PEPSI AND COCA-COLA TO ABANDON ANIMAL TESTING

The radical animal welfare group People for the Ethical Treatment of Animals has scored a big win in its campaign to stop animal testing of food products. Soft drink giants Pepsi and Coca-Cola have agreed to stop directly financing such research unless it is mandated by law. They are the largest manufacturers to agree to such a ban. "We see these statements from Coke and Pepsi, massive global conglomerates, as the beginning of the end of all animal tests on food," said a PETA representative. ~ New York Times, May 31   

IVF BEGINS IN UGANDA

Glowing newspaper profiles of IVF doctors who bring bundles of joy to desperate couples are common enough in the US, the UK and Australia. But it is seldom that they emphasise how often the doctor consults the Bible for guidance. Recently, the Kampala Monitor profiled Dr Edward Tamale Ssali, who practices in Bukoto, in southern Uganda. He is responsible for the first birth of a frozen embryo baby and the first birth to a surrogate mother in East and Central Africa. A devout Christian, he rises every day at 5am and reads his Bible. He also hosts a TV program, Faith and Science, on Sundays. "I would be earning a lot overseas but I decided to station here," he told the Monitor. "There is more to life than money. The Bible says that the life of a man doesn't consist in the things that he owns." ~ Monitor, Jun 3   

SWISS SUICIDE CLINIC UNDER ATTACK

Despite the publicity given to Swiss suicide clinics, not all Swiss are happy with a law which allows foreigners to seek help in killing themselves. Prosecutors in Zurich are now calling for an investigation into claims that some patients are merely depressed and not terminally ill or suffering incurable pain. Some foreigners die within hours of arriving in Switzerland, which suggests that they have not been given a thorough medical and psychological examination.

Andreas Brunner, the senior prosecutor of the Zurich canton, told the London Sunday Telegraph: "We are not trying to ban the so-called death tourism, but the outsourcing of suicide must be put under stricter control... There are many cases where it is not clear whether the assisted person has chosen death in full possession of their decision-making capacity. But investigations are difficult due to lack of evidence after the suicide."

The founder of the suicide group Dignitas, Ludwig Minelli, dismissed Mr Brunner's complaint and accused him of crusading against his organisation. "If the investigations had a real basis I would have been summoned for questioning, but this has not yet happened," he said. ~ London Sunday Telegraph, June 3   

SPERM DONORS UNDERVALUED, SAYS STUDY

The fertility industry discriminates against sperm donors, says US sociologist Rene Almeling. Her article this month in the American Sociological Review describes striking inequities in the market for eggs and sperm which, she says, reflect "gendered stereotypes of selfless motherhood and distant fatherhood".

"Staff at egg agencies constantly thank women and encourage them to think about what a wonderful difference they're making in the lives of recipients," Almeling says. "The sperm bank staff is appreciative, but men aren't told how amazing they are and what a great gift they're giving. They're treated more like reproductive service workers. They come in. They clock in and out. Their sample is checked for quality. And they're only paid when they produce an acceptable sample."

In the market for American gametes, men are typically paid between US$50 and US$75 per donation, while women are paid around $5,000, along with bonuses and thank-you cards. While it is commonly believed that sperm donors are readily available, in fact, few potential male donors meet the standards required by the clinics, while there is an oversupply of women donors. Almeling is investigating why the laws of supply and demand do not appear to work in the gamete market. ~ News-Medical.Net, May 27   

KEVORKIAN LEAVES JAIL

Jack Kevorkian, the American doctor jailed after assisting with more 130 suicides, has been paroled from a Michigan jail. In an interview with the New York Times, the frail 79-year-old was unrepentant, but promised not to violate the conditions of his parole by advising people on how to die. However, he has lost none of spark that has made him a celebrity, calling the government tyrannical, the public "sheep", and his critics "religious fanatics or nuts".

He is considering speaking engagements advocating assisted suicide, although the conditions of his parole will prevent him from going into too much detail. He told the Times that he had never been bothered by his nickname, Doctor Death. "They're right in a way," he said, since his focus as a former pathologist, was death and dying. "Everyone is going to die. Aren't you interested in what's going to happen?" ~ New York Times, Jun 4   

MEDICAL TOURISM SOARING

International medical tourism has become a US$60 billion industry which is growing at the galloping pace of 20% a year. Patients in Europe and North America seeking bargains or speedier treatment are travelling to countries like India, Brazil and Thailand for medicine which is as good or better than what they could afford at home. India will treat half a million overseas patients this year, for instance.

The trend has increased since the Asian currency crisis between 1997 and 2001, and 9/11, because Asians and Arabs were effectively unable to travel to the US for treatment. Savvy medical administrators sensed an opportunity and stepped into the gap. In some instances, the quality of medicine is outstanding.

According to Ruben Toral, a marketing manager for a Bangkok-based hospital, the typical medical tourist is someone over 50 who wants elective surgery or a medical procedure on a budget. His hospital pays its doctors lower wages and runs a strictly cash business.

At a seminar on international medical tourism in Las Vegas earlier this month, however, some concerns about the trend emerged. In many of these countries medical liability is not well developed. Although there is little hard information, some procedures have required reparative surgery back home. A recent survey of 68 Australian plastic surgeons uncovered 100 instances of botched procedures after women took "cosmetic surgery holidays" in Thailand and Malaysia.

What does the future hold? Perhaps the globalisation of medicine, as baby boomers go abroad for their operations. The Lancet cites an expert who predicts that insurance companies will develop products specifically for the medical tourism market and developing countries will build hospitals to capitalise on their relatively low labour costs. ~ Lancet, Jun 2   

IN BRIEF: sextuplets; assisted suicide; coma

Foetal reduction: A Florida woman on fertility treatment is pregnant with sextuplets. Karoline Byler and her husband Ben were shocked. But when doctors suggested foetal reduction - killing two foetuses to give the others a better chance of survival - they refused. "People have done this before," she says. "It's rare, but it obviously can be done." The first surviving set of sextuplets was born in Indiana in 1993. ~ St Petersburg Times, June 1

Assisted suicide: The National Hospice and Palliative Care Organization in the US has issued a statement opposing the legalisation of physician-assisted suicide. "When symptoms or circumstances become intolerable to a patient, effective therapies are now available to assure relief from almost all forms of distress during the terminal phase of an illness without purposefully hastening death as a means to that end," it says. ~ statement

Coma man awakes: After nearly two decades in a coma, a Polish railway worker has woken up. Newspaper accounts highlighted the changes he had missed -- the fall of Communism, the introduction of private enterprise, and the rise of consumerism. Jan Grzebska was injured in an industrial accident in 1988. His wife nursed him for 19 years. Mr Grzebska says that he dimly remembers the efforts of his family to communicate with him. ~ Reuters, Jun 2   

  

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Australasian Bioethics Information
ISSN 1446-2117
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BioEdge editor: Michael Cook
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