James Watson's colleagues at Cold Spring Harbor Laboratory in New York have scuttled for cover after the Nobel Prize laureate was accused of making racist remarks. "Bewildered and saddened" by his remarks in the London Times, they have dismissed him as Chancellor, even though Watson had served as its director or president for 35 years. The 79-year-old Nobel laureate has cancelled a tour of the UK to promote his book Avoid Boring People and returned to the US.
Although Watson's belief that Africans have lower IQs on average was inflammatory in itself, CSHL had another reason for distancing itself from Watson. The research institute was once the centre of the American eugenics movement. Its shameful association with scientific racism and compulsory sterilisation ended in 1940 and it has been trying to distance itself from its past ever since. In a press release, it stressed that it did not "engage in any research that could even form the basis of the statements attributed to Dr. Watson."
From 1910 to 1939 CSHL housed the Eugenics Record Office, which catalogued medical histories of families, carefully noting traits such as allergies, feeble-mindedness, civic leadership and immoral behaviour. At the time, the aim was to foster breeding of healthy citizens, as James Watson himself explains in short video clips on an educational website set up by CSHL.
The first CSHL director, Charles Davenport, was convinced that Mendel's laws could be applied to humans. The managing director, Harry Laughlin, was responsible for drafting a "model law" for compulsory sterilisation for the insane, criminals, epileptics, alcoholics, blind persons, deaf persons, deformed persons, and indigent persons. This was taken up by a number of American states and even used as a model for eugenics legislation in Nazi Germany.
Although Watson is notorious for promoting eugenics -- rebadged as genetic engineering -- the American scientific community has only reacted to his negative comments on blacks. "He has failed us in the worst possible way. It is a sad and revolting way to end a remarkable career," said Henry Kelly, president of the Federation of American Scientists.
In the UK, however, many scientists are reported to be incensed by the censorship of Watson's views. The former head of the Medical Research Council, Colin Blakemore, commented that "Jim Watson is well known for being provocative and politically incorrect. But it would be a sad world if such a distinguished scientist was silenced because of his more unpalatable views." ~ Science, Oct 19; London Times, Oct 21
Getting rich is in your genes
The burgeoning enthusiasm for genetic explanations of everything has emerged in economics. In one of the year's best-sellers, A Farewell to Alms, economic historian Gregory Clark argues that it is not changes in institutions but changes in people which determine the course of history. "The triumph of capitalism in the modern world thus may lie as much in our genes as in ideology or rationality," he says.
One of the key questions in economic history is why the Industrial Revolution took place in England. Clark bases his answers on his research into the reproductive success of wealthy Englishmen. After 1250, rich commoners had more surviving children than the rest, and their children, too, had higher-than-average reproductive success. This meant that the distinctive values which had made them prosperous percolated throughout society, eventually leading to Britain's economic take-off in the late 18th century.
What was being inherited was not necessarily intelligence, but a whole spectrum of desirable character traits which turned England into a hugely successful economy, such as non-violence, literacy, long working hours and a willingness to save. ~ Science, Oct 19; New York Times, Aug 7
Italy's Terri Schiavo
Italian courts are grappling with their own Terri Schiavo, a 34- year-old woman, Eluana Englaro, who has been in a coma for 15 years after an automotive accident. Her elderly father, Beppino, wants to turn off her feeding tube because she is living in an "inhuman and degrading condition".
The case has been working its way through the courts. A year ago, a court in Milan refused to authorise removal of nutrition and hydration. But earlier this month, Italy's highest appeals court ordered a retrial. The Cassation Court declared that a person's right to decide what medical treatment they receive should be respected even if doing so would cause their death.
Doctors say Eluana will never regain consciousness. Otherwise, however, she is healthy and has never required life-support systems. Her father asserts that she said plainly during her conscious life that she would not wish to live in a vegetative state. He has often compared her situation with Terri Schiavo's. ~ ANSA, Oct 16; International Herald Tribune, May 15
NIH chief snubs Bush stem cell policy
Can President Bush's weakening hold on Washington bureaucracy be detected in its bioethics? The head of the National Institutes of Health, Elias Zerhouni, has again contradicted his boss's stand on stem cell research. In the latest issue of a popular magazine published by the NIH, Medline Plus, Dr Zerhouni argues strongly for expanding research on human embryos. "All avenues of research need to be pursued. We must continue the research at all levels, or there will be no progress," he writes.
Dr Zerhouni told a Congressional committee in March that current restrictions on embryonic stem cell research ought to be lifted. A White House spokesman responded that the President had to take a "broader view" than a scientist, including "moral and religious views". ~ Washington Post, Oct 17
Too early to offer egg-freezing, say experts
Despite claims by a number of clinics that egg freezing is a viable option for women who want to defer childbearing, the peak IVF body in the United States has knocked the idea on the head at the annual American Society for Reproductive Medicine conference. The ASRM has warned that the live birth rate could be as low as 2% per thawed egg.
Dr Marc Fritz, of the ASRM's practice committee, says: "Egg-freezing is still an experimental procedure. It should not be marketed for the purposes of defying the consequences of reproductive ageing in healthy women. One concern is that having frozen their eggs women may unfortunately think they have ensured their future fertility. Existing medical evidence simply does not justify that. Women contemplating the use of egg-freezing technologies need to receive extensive counselling to help them make a fully informed decision."
However, Dr Gillian Lockwood, a prominent British IVF doctor, defended the right of women to try their luck. "The vast majority of women who come to me for egg freezing long to be in a relationship where they have a baby in the old fashioned way and it's all champagne and roses. But they have sometimes just been left by a commitment-phobic man at the age of 37, have been looking after elderly parents or they are part of a couple that needs two salaries to get a mortgage. They say the fact they know there's a chance of success using frozen eggs means they are not quite so desperate to get a man and on a first date drag him down to a clinic and ask him for his views on fatherhood." ~ London Telegraph, Oct 20
Commercial saviour sibling scheme criticised
A company offering to bank frozen embryos in case a sibling might need tissue-matched organs later in life has been denounced by IVF scientists at the American Society for Reproductive Medicine Conference in Washington. The California-based company StemLifeLine claims that embryos can be "transformed" into individual stem cell lines which can create therapies.
However British stem cell experts have called for a reality check. The doyen of British IVF, Lord Robert Winston, said the company was preying on parents' fears. "It's a clear example of exploitation of the worries of couples about the fate of their children. There is no scientific evidence to sustain the notion that this will be a useful procedure. I would be horrified if anyone tried to do this in Britain."
And Professor Stephen Minger, of King's College London said that the idea was profit-driven. "My worry is that this is a commercial service that is being promoted to companies when the science is really not there to justify it. It is like trying to run before you can walk, and the fact it is being done for commercial purposes makes it worse." ~ BBC, Oct 15
UK babies aborted for trivial defects
More than 100 babies with minor disabilities, such as a cleft palate or club foot, were aborted in just one region of England between 2002 and 2005. According to government figures 54 babies in south- west England with club feet, 37 with cleft palates or lips, and 26 with extra or webbed fingers or toes were terminated.
All of these defects could be corrected with minor surgery. Club feet is one of the commonest birth defects, but it can be corrected without surgery, with splints, plaster casts and boots. However, some parents and doctors still believe that it is a serious birth defect.
The UK's Abortion Act allows termination at any stage of pregnancy if two doctors agree that there is a "substantial risk" of the child being "serious handicapped". What constitutes "substantial risk" is left to the doctors' discretion, and some fear the definition of "handicap" is widening as scanning technology develops.
The data on birth defects were released as a Parliamentary committee considers whether to recommend scrapping a 24-week upper limit for abortions. It is also considering whether a requirement for the written approval of two doctors should be abolished and whether nurses should be permitted to perform early-stage abortions. ~ London Telegraph, Oct 22
Fat to become nerves
Accident victims could have nerves restored with the help of stem cells from their own fat. Scientists at the University of Manchester in the UK have managed to transform fat stem cells into nerve cells. They hope to use these to create artificial nerves to restore movement to damaged limbs. If all goes well, clinical trials could begin within three or four years, according to Professor Giorgio Terenghi.
In a study reported in the journal Experimental Neurology, the Manchester team succeeded in creating nerve cells in animals. The next steps are to wrap the nerve cells up in a biodegradable polymer tube and then to insert it between the two ends of the severed nerve so that it can regenerate. ~ London Telegraph, Oct 18
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